Table of Contents Author Guidelines Submit a Manuscript
Obstetrics and Gynecology International
Volume 2013, Article ID 636459, 7 pages
Research Article

Women’s Attitudes towards the Option to Choose between Karyotyping and Rapid Targeted Testing during Pregnancy

1Department of Human Genetics, Radboud University Medical Centre, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands
2Department of Obstetrics and Gynaecology, Rijnstate Hospital, 6815 AD Arnhem, The Netherlands
3Department of Obstetrics and Gynaecology, Jeroen Bosch Hospital, 5200 ME ‘s-Hertogenbosch, The Netherlands
4Department of Obstetrics and Gynaecology, Medical Spectrum Twente, 7500 KA Enschede, The Netherlands
5Department of Obstetrics and Gynaecology, St. Elisabeth Hospital, 5022 GC Tilburg, The Netherlands
6Department of Obstetrics and Gynaecology, Radboud University Medical Centre, 6500 HB Nijmegen, The Netherlands

Received 15 January 2013; Revised 7 April 2013; Accepted 11 April 2013

Academic Editor: Everett Magann

Copyright © 2013 Angelique J. A. Kooper et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Objectives. Pregnant women, referred because of an increased risk of fetal Down syndrome, who underwent an invasive prenatal procedure were offered a choice between karyotyping and rapid targeted testing. This study aims to assess women’s attitudes and experiences towards what option to choose. Methods. A retrospective multicentre survey (2008–2010) was conducted among 1370 women. General questions were asked about decision making issues, followed by personal questions about their experiences in choice making, test preference, influence of others, and possible regrets. Results. In total, 90.1% of the respondents ( ) indicated that pregnant women are able to choose, although 33.1% stated that the choice can best be made by a professional. 18.4% indicated that making a choice places a burden on women. In 96.4%, respondents preferred to have the option to choose again in case of a next pregnancy, whereas 2.7% preferred the choice to be made by a professional. Regret was indicated by 1.2%. Decision making was influenced by others in 64.9%. A slightly higher preference for karyotyping was indicated by 52.7% of the respondents. Conclusions. Positive attitudes and experiences were expressed towards the option to choose. Respondents took decisions freely, although sometimes influenced by a partner or a professional, to follow their individual perspectives.