Table 3: Comments from the respondents who showed regret about their choice.

Case ID Test of choice Comment Type of comment AgeHospital

59Karyotyping “There was too little amniotic fluid to perform karyotyping and therefore a rapid targeted test was the alternative test. I preferred karyotyping.”Technical aspect 39E
171Karyotyping“The option to choose was offered just before the procedure. I had my doubts and subsequently, I regret my decision.”Personal aspect 39B
266Rapid targeted test“Later in pregnancy a fetal heart defect was detected, possibly caused by a chromosomal aberration”Medical aspect 40B
463Rapid targeted test“Our test of choice was a rapid targeted test, contamination with blood made the test result unreliable. Unfortunately, we had to wait 3 weeks to obtain the karyotyping result”Technical aspect 39B
673Karyotyping“I will never make that choice again”Personal aspect 33A
725Rapid targeted test“Later in pregnancy a fetal heart defect was detected. We were uncertain whether this was caused by a chromosomal aberration”Medical aspect38E
729Unknown“It went against all my feelings”Personal aspect 40A
745Rapid targeted test“In my previous pregnancy karyotyping was performed. It feels better when they examine more”Personal aspect38E