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Obstetrics and Gynecology International
Volume 2013 (2013), Article ID 757249, 7 pages
Review Article

Management of Early Stage, High-Risk Endometrial Carcinoma: Preoperative and Surgical Considerations

Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University Hospitals Case Medical Center, Cleveland, OH 44106, USA

Received 11 April 2013; Accepted 28 May 2013

Academic Editor: Howard D. Homesley

Copyright © 2013 Sareena Singh et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Endometrial cancer is the most common gynecologic malignancy in the developed world. Most cases are diagnosed at an early stage and have low-grade histology, portending an overall excellent prognosis. There exists a subgroup of patients with early, high-risk disease, whose management remains controversial, as current data is clouded by inclusion of early stage tumors with different high-risk features for recurrence, unstandardized protocols for surgical staging, and an evolving staging system by which we are grouping these patients. Here, we present preoperative and intraoperative considerations that should be taken into account when planning surgical management for this population of patients.