Strategies for Molecularly Enhanced Chemotherapy to Achieve Synthetic Lethality in Endometrial Tumors with Mutant p53
Figure 2
Angiokinase inhibitor BIBF1120 increases sensitivity to paclitaxel in parental and paclitaxel-resistant Hec50 cells. (a–c) Parental Hec50 (a) or paclitaxel-resistant Hec50A (b) or Hec50E (c) endometrial cancer cells, which are p53-null, were treated with increasing concentrations of paclitaxel in the absence or presence of 1 μM BIBF1120 for 72 h, followed by assessment of cell viability using the Wst-1 assay. (d, e) Parental Hec50 or paclitaxel-resistant Hec50A or Hec50E endometrial cancer cells were treated with increasing concentrations of BIBF1120 in the absence (d) or presence (e) of 10 nM paclitaxel for 72 h, followed by assessment of cell viability using the Wst-1 assay.
