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Obstetrics and Gynecology International
Volume 2014 (2014), Article ID 141020, 5 pages
http://dx.doi.org/10.1155/2014/141020
Clinical Study

The Efficacy of Inositol and N-Acetyl Cysteine Administration (Ovaric HP) in Improving the Ovarian Function in Infertile Women with PCOS with or without Insulin Resistance

Unit of Obstetrics and Gynaecology, Department of Experimental and Clinical Medicine, “Magna Graecia” University, Viale Europa, Germaneto, 88100 Catanzaro, Italy

Received 28 February 2014; Accepted 10 April 2014; Published 30 April 2014

Academic Editor: Liselotte Mettler

Copyright © 2014 Angela Sacchinelli et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. S. M. Sirmans and K. A. Pate, “Epidemiology, diagnosis, and management of polycystic ovary syndrome,” Journal of Clinical Epidemiology, vol. 6, pp. 1–13, 2013. View at Google Scholar
  2. T. M. Barber, M. I. McCarthy, J. A. H. Wass, and S. Franks, “Obesity and polycystic ovary syndrome,” Clinical Endocrinology, vol. 65, no. 2, pp. 137–145, 2006. View at Publisher · View at Google Scholar · View at Scopus
  3. Z. Bu, K. Kuok, J. Meng, R. Wang, B. Xu, and H. Zhang, “The relationship between polycystic ovary syndrome, glucose tolerance status and serum preptin level,” Reproductive Biology and Endocrinology, vol. 10, article 10, 2012. View at Publisher · View at Google Scholar · View at Scopus
  4. S. Wu, S. Divall, A. Nwaopara et al., “Obesity induced infertility and hyperandrogenism are corrected by deletion of the insulin receptor in the ovarian theca cell,” Diabetes, 2013. View at Publisher · View at Google Scholar
  5. R. D. Utiger, “Insulin and the polycystic ovary syndrome,” The New England Journal of Medicine, vol. 335, no. 9, pp. 657–658, 1996. View at Publisher · View at Google Scholar · View at Scopus
  6. E. Papaleo, V. Unfer, J.-P. Baillargeon et al., “Myo-inositol in patients with polycystic ovary syndrome: a novel method for ovulation induction,” Gynecological Endocrinology, vol. 23, no. 12, pp. 700–703, 2007. View at Publisher · View at Google Scholar · View at Scopus
  7. S. Gerli, E. Papaleo, A. Ferrari, and G. C. di Renzo, “Randomized, double blind placebo-controlled trial: effects of Myo-inositol on ovarian function and metabolic factors in women with PCOS,” European Review for Medical and Pharmacological Sciences, vol. 11, no. 5, pp. 347–354, 2007. View at Google Scholar · View at Scopus
  8. H. P. T. Ammon, K.-H. Hehl, and G. Enz, “Cysteine analogues potentiate glucose-induced insulin release in vitro,” Diabetes, vol. 35, no. 12, pp. 1390–1396, 1986. View at Google Scholar · View at Scopus
  9. H. P. T. Ammon, P. H. Muller, M. Eggstein et al., “Increase in glucose consumption by acetylcysteine during hyperglycemic clamp. A study with healthy volunteers,” Arzneimittel-Forschung/Drug Research, vol. 42, no. 5, pp. 642–645, 1992. View at Google Scholar · View at Scopus
  10. M. T. Santini, C. Cametti, P. L. Indovina, and S. W. Peterson, “Menadione induces changes in the membrane electrical properties associated with downregulation of insulin receptors in human erythrocytes,” Experimental Hematology, vol. 26, no. 6, pp. 466–471, 1998. View at Google Scholar · View at Scopus
  11. Organizzazione Editoriale Medico Farmaceutica spa, “Fluimucil 600 zambon,” in Italian Directory of Medicines and Manufactures, Part 1, p. 435, 60th edition, 2000. View at Google Scholar
  12. G. De Mattia, M. C. Bravi, O. Laurenti et al., “Reduction of oxidative stress by oral N-acetyl-L-cysteine treatment decreases plasma soluble vascular cell adhesion molecule-1 concentrations in non-obese, non-dyslipidaemic, normotensive, patients with non-insulin- dependent diabetes,” Diabetologia, vol. 41, no. 11, pp. 1392–1396, 1998. View at Publisher · View at Google Scholar · View at Scopus
  13. K. I. Cheang, J. M. Huszar, A. M. Best, S. Sharma, P. A. Essah, and J. E. Nestler, “Long-term effect of metformin on metabolic parameters in the polycystic ovary syndrome,” Diabetes and Vascular Disease Research, vol. 6, no. 2, pp. 110–119, 2009. View at Publisher · View at Google Scholar · View at Scopus
  14. V. Unfer, G. Carlomagno, G. Dante, and F. Facchinetti, “Effects of myo-inositol in women with PCOS: a systematic review of randomized controlled trials,” Gynecological Endocrinology, vol. 28, no. 7, pp. 509–515, 2012. View at Google Scholar
  15. R. Agrawal, E. Burt, A. M. Gallagher, L. Butler, R. Venkatakrishnan, and P. Peitsidis, “Prospective randomized trial of multiple micronutrients in subfertile women undergoing ovulation induction: a pilot study,” Reproductive BioMedicine Online, vol. 24, no. 1, pp. 54–60, 2012. View at Publisher · View at Google Scholar · View at Scopus