In Women with Previous Pregnancy Hypertension, Levels of Cardiovascular Risk Biomarkers May Be Modulated by Haptoglobin Polymorphism

Table 6

Characterization of four distinguished groups in conformity of hypertension classification and the anthropometric, hemodynamic, cardiovascular risk biomarkers and other biochemical parameters.

	[PE > HTA] (1)	[PE > NBP] (2)	[NBPP > HTA] (3)	[NBPP > NBP] (4)	𝑃 value
					(1)*; versus; (2)	(1); versus; (3)	(2); versus; (3)	(2); versus; (4)	(3); versus; (4)	(1); versus; (4)
Age (years)^†	42 (36.64±5.16)	46 (33.50±5.29)	6 (36.33±4.97)	52 (35.50±5.78)	0.008	0.891	0.220	0.079	0.737	0.320
BMI (Kg/m^2)^†	42 (27.22±5.00)	45 (26.85±4.69)	6 (28.71±5.11)	51 (24.97±3.83)	0.830	0.500	0.373	0.033	0.033	0.016
WC (cm)^†	42 (90.56±18.96)	45 (88.38±12.01)	6 (89.00±15.11)	49 (82.06±9.04)	0.516	0.848	0.908	0.005	0.107	0.010
Systolic BP (mmHg)^†	42 (145.88±16.11)	46 (125.04±8.85)	6 (140.00±6.23)	52 (116.44±11.73)	<0.001	0.384	<0.001	<0.001	<0.001	<0.001
Diastolic BP (mmHg)^†	42 (98.90±16.26)	46 (74.09 ± 10.22)	6 (86.00±5.87)	52 (70.62±9.23)	<0.001	0.062	0.008	0.080	<0.001	<0.001
Pulse pressure^†	42 (46.98±14.68)	46 (50.96±8.38)	6 (54.00±9.53)	52 (45.83±8.90)	0.144	0.263	0.413	0.004	0.040	0.658
CRP (mg/L)^††	38 (0.60±0.13)	44 (0.60±0.07)	6 (0.70±0.24)	49 (0.40±0.12)	0.388	0.350	0.404	0.079	0.055	0.188
MPO (ng/mL)^†	7 (82.74±11.04)	25 (86.49±44.39)	3 (86.83±24.08)	20 (60.86±29.78)	0.781	0.710	0.990	0.032	0.167	0.010
Nitrites (mol/L)^†	7 (23.04±13.07)	25 (18.02±3.89)	3 (9.00±0.00)	21 (9.84±3.56)	0.190	0.110	<0.001	<0.001	0.693	0.037
NO𝑥 (mol/L)^†	6 (109.70±40.96)	23 (96.77±39.62)	3 (91.47±63.01)	21 (78.63±35.86)	0.474	0.610	0.839	0.120	0.600	0.134
AST (UI/L)^††	42 (19.00±0.84)	46 (20.00±1.19)	6 (17.50±1.25)	52 (18.00±0.66)	0.589	0.190	0.188	0.108	0.564	0.230
ALT (UI/L)^††	42 (19.00±1.85)	46 (19.00±2.07)	6 (15.50±1.01)	52 (15.50±1.17)	0.809	0.110	0.121	0.021	0.878	0.031
t-Cholesterol (mg/dL)^†	42 (202.48±42.02)	46 (210.35±37.72)	6 (205.17±14.10)	52 (207.48±36.36)	0.267	0.878	0.739	0.701	0.879	0.538
Non HDL cholesterol^†	42 (154.98±38.86)	46 (159.80±37.72)	6 (154.17±15.03)	51 (158.16±37.66)	0.392	0.960	0.721	0.830	0.799	0.690
LDL (mg/dL)^†	42 (136.54±37.97)	46 (137.74±40.55)	6 (133.87±10.29)	51 (140.25±34.05)	0.632	0.866	0.818	0.741	0.326	0.690
HDL (mg/dL)^††	42 (47.00±1.29)	46 (53.00±1.24)	6 (52.00±3.54)	51 (50.00±1.21)	0.172	0.367	0.878	0.580	0.677	0.130
Apo A (mg/dL)^†	40 (0.97±0.18)	45 (1.01±0.16)	6 (0.94 ± 0.17)	50 (0.95±0.21)	0.320	0.698	0.370	0.128	0.952	0.548
Apo B (mg/dL)^†	40 (0.63±0.14)	45 (0.65 ± 0.13)	6 (0.60±0.06)	50 (0.59±0.14)	0.704	0.584	0.387	0.040	0.866	0.159

†Independent sample 𝑡-test; and values are means ± standard deviation (SD); ††Mann-Whitney 𝑈 test; and values are median ± standard error (SE). Relative to 𝑃 value of (1) versus (2)*, values were adjusted for age (regression binary logistic).
Preeclamptic women (PE); hypertension after pregnancy (HTA), normal blood pressure in pregnancy (NBPP), normotensive after pregnancy (NBP), waist circumference (WC), Body mass index (BMI), systolic blood pressure (systolic BP), diastolic blood pressure (diastolic BP), c-reactive protein (CRP), myeloperoxidase (MPO), nitrites, total nitric oxide (NO_𝑥), aspartate transaminase (AST); alanine transaminase (ALT), low density lipoprotein (LDL) and high density lipoprotein (HDL), and apolipoprotein A and B (Apo A and Apo B).