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Obstetrics and Gynecology International
Volume 2014 (2014), Article ID 423708, 6 pages
Clinical Study

Predictors of Success of Different Treatment Modalities for Management of Ectopic Pregnancy

1Department of Gynecology and Obstetrics, School of Medicine, Adnan Menderes University, 09010 Aydın, Turkey
2Department of Gynecology and Obstetrics, School of Medicine, Muğla Sıtkı Koçman University, 48000 Muğla, Turkey

Received 12 July 2014; Accepted 26 November 2014; Published 14 December 2014

Academic Editor: Thomas Herzog

Copyright © 2014 Sümeyra Nergiz Avcioğlu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Aim. The purpose of this study was to investigate factors affecting the success of different treatment modalities for the management of ectopic pregnancy (EP). Methods. One hundred and ninety-seven patients with EP, were included in the study. Patients were treated with either intramuscular methotrexate (Mtx) or surgical treatment. Results. Mtx was applied in 97 (49.2%) patients. In 67 patients (69.1%), a single dose of Mtx and in 30 patients (30.9%) a multiple dose of Mtx was applied. Forty-seven (70.14%) patients were successfully treated with a single-dose Mtx. In the multiple-dose group, the success rate was 70% (21/30 patients). The difference between the success rates was not statistically significant. When the initial serum βhCG value was <1000 mIU/mL, the overall success rate of Mtx treatment was determined to be 86.11%; however, the rate decreased to 42.3% when the βhCG value was >3000 mIU/mL. On the other hand, if the EP mass diameter was <25 mm, the success rate was 89.28% and decreased to 52.63% when it was 25 mm. Conclusion. The results of the study showed that single-dose treatment with Mtx could be as successful as multiple doses. Overall success of Mtx treatment depended on initial βhCG value and EP mass diameter.