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Obstetrics and Gynecology International
Volume 2014, Article ID 678984, 5 pages
http://dx.doi.org/10.1155/2014/678984
Research Article

Placenta-Specific Protein 1: A Potential Key to Many Oncofetal-Placental OB/GYN Research Questions

1Department of Obstetrics and Gynecology, University of Iowa Carver College of Medicine, 3234 MERF, Iowa City, IA 52242, USA
2Lincoln University, Lincoln University, Pennsylvania, PA 19352, USA
3Holden Comprehensive Cancer Center, University of Iowa Hospitals and Clinics, Iowa City, IA 52242, USA

Received 19 November 2013; Revised 23 January 2014; Accepted 10 February 2014; Published 17 March 2014

Academic Editor: Robert Coleman

Copyright © 2014 Eric J. Devor et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. M. Cocchia, R. Huber, S. Pantano et al., “PLAC1, an Xq26 gene with placenta-specific expression,” Genomics, vol. 68, no. 3, pp. 305–312, 2000. View at Publisher · View at Google Scholar · View at Scopus
  2. M. Fant, H. Barerra-Saldana, W. Dubinsky, B. Poindexter, and R. Bick, “The PLAC1 protein localizes to membranous compartments in the apical region of the syncytiotrophoblast,” Molecular Reproduction and Development, vol. 74, no. 7, pp. 922–929, 2007. View at Publisher · View at Google Scholar · View at Scopus
  3. S. M. Jackman, X. Kong, and M. E. Fant, “Plac1 (Placenta-specific 1) is essential for normal placental development,” Molecular Reproduction and Development, vol. 79, no. 8, pp. 564–572, 2012. View at Publisher · View at Google Scholar
  4. W. A. Silva Jr., S. Gnjatic, E. Ritter et al., “PLAC1, a trophoblast-specific cell surface protein, is expressed in a range of human tumors and elicits spontaneous antibody responses,” Cancer Immunity, vol. 7, article 18, 2007. View at Google Scholar · View at Scopus
  5. M. Koslowski, U. Sahin, R. Mitnacht-Kraus, G. Seitz, C. Huber, and Ö. Türeci, “A placenta-specific gene ectopically activated in many human cancers is essentially involved in malignant cell processes,” Cancer Research, vol. 67, no. 19, pp. 9528–9534, 2007. View at Publisher · View at Google Scholar · View at Scopus
  6. X.-Y. Dong, J.-R. Peng, Y.-J. Ye et al., “PLAC1 is a tumor-specific antigen capable of eliciting spontaneous antibody responses in human cancer patients,” International Journal of Cancer, vol. 122, no. 9, pp. 2038–2043, 2008. View at Publisher · View at Google Scholar · View at Scopus
  7. F.-F. Liu, X.-Y. Dong, X.-W. Pang et al., “The specific immune response to tumor antigen CP1 and its correlation with improved survival in colon cancer patients,” Gastroenterology, vol. 134, no. 4, pp. 998–1006, 2008. View at Publisher · View at Google Scholar · View at Scopus
  8. J. Chen, X. W. Pang, F. F. Liu et al., “PLAC1/CP1 gene expression and autologous humoral immunity in gastric cancer patients,” Beijing Da Xue Xue Bao, vol. 38, pp. 124–127, 2006 (Chinese). View at Google Scholar
  9. E. J. Devor and K. K. Leslie, “The oncoplacental gene placenta-specific protein 1 (PLAC1) is highly expressed in endometrial tumors and cell lines,” Obstetrics and Gynecology International, vol. 2013, Article ID 807849, 7 pages, 2013. View at Publisher · View at Google Scholar
  10. L. J. Old, “Cancer is a somatic cell pregnancy,” Cancer Immunity, vol. 7, article 19, 2007. View at Google Scholar · View at Scopus
  11. X. Kong, S. M. Jackman, and M. E. Fant, “Plac1 (placenta-specific 1) is widely expressed during fetal development and is associated with a lethal form of hydrocephalus,” Birth Defects Research, vol. 97, no. 9, pp. 571–577, 2013. View at Publisher · View at Google Scholar
  12. Y. Chen, A. Moradin, D. Schlessinger, and R. Nagaraja, “RXRα and LXR activate two promoters in placenta- and tumor-specific expression of PLAC1,” Placenta, vol. 32, no. 11, pp. 877–884, 2011. View at Publisher · View at Google Scholar · View at Scopus
  13. M. Koslowski, Ö. Türeci, S. Biesterfeld, G. Seitz, C. Huber, and U. Sahin, “Selective activation of trophoblast-specific PLAC1 in breast cancer by CCAAT/enhancer-binding protein β (C/EBP β) isoform 2,” The Journal of Biological Chemistry, vol. 284, no. 42, pp. 28607–28615, 2009. View at Publisher · View at Google Scholar · View at Scopus
  14. M. Wagner, M. Koslowski, C. Paret, M. Schmidt, Ö. Türeci, and U. Sahir, “NCOA3 is a selective co-activator of estrogen receptor α-mediated transactivation of PLAC1 in MCF-7 breast cancer cells,” BMC Cancer, vol. 13, article 570, 2013. View at Publisher · View at Google Scholar
  15. A. Schroeder, O. Mueller, S. Stocker et al., “The RIN: an RNA integrity number for assigning integrity values to RNA measurements,” BMC Molecular Biology, vol. 7, article 3, 2006. View at Publisher · View at Google Scholar · View at Scopus
  16. K. J. Livak and T. D. Schmittgen, “Analysis of relative gene expression data using real-time quantitative PCR and the 2-ΔΔCT method,” Methods, vol. 25, no. 4, pp. 402–408, 2001. View at Publisher · View at Google Scholar · View at Scopus
  17. T. D. Schmittgen and K. J. Livak, “Analyzing real-time PCR data by the comparative CT method,” Nature Protocols, vol. 3, no. 6, pp. 1101–1108, 2008. View at Publisher · View at Google Scholar · View at Scopus
  18. G. W. Snedecor and W. G. Cochran, Statistical Methods, Iowa State University Press, Ames, Iowa, USA, 8th edition, 1989.
  19. N. Rizzo, I. Banzola, M. Concu et al., “PLAC1 mRNA levels in maternal blood at induction of labor correlate negatively with induction-delivery interval,” European Journal of Obstetrics Gynecology and Reproductive Biology, vol. 132, no. 2, pp. 177–181, 2007. View at Publisher · View at Google Scholar · View at Scopus
  20. Y. Rodriguez-Prado, X. Kong, and M. Fant, “PLAC1 expression decreases in chorionic villi in response to labor,” ISRN Obstetrics and Gynecology, vol. 2013, Article ID 704252, 4 pages, 2013. View at Publisher · View at Google Scholar
  21. M. Fant, D. L. Weisoly, M. Cocchia et al., “PLAC1, a trophoblast-specific gene, is expressed throughout pregnancy in the human placenta and modulated by keratinocyte growth factor,” Molecular Reproduction and Development, vol. 63, no. 4, pp. 430–436, 2002. View at Publisher · View at Google Scholar · View at Scopus
  22. N. Fujito, O. Samura, N. Miharu, M. Tanigawa, M. Hyodo, and Y. Kudo, “Increased plasma mRNAs of placenta-specific 1 (PLAC1) and glial cells-missing 1 (GCM1) in mothers with pre-eclampsia,” Hiroshima Journal of Medical Sciences, vol. 55, no. 1, pp. 9–15, 2006. View at Google Scholar · View at Scopus
  23. Y. Purwosunu, A. Sekizawa, A. Farina et al., “Cell-free mRNA concentrations of CRH, PLAC1, and selectin-P are increased in the plasma of pregnant women with preeclampsia,” Prenatal Diagnosis, vol. 27, no. 8, pp. 772–777, 2007. View at Publisher · View at Google Scholar · View at Scopus
  24. M. Kodama, H. Miyoshi, N. Fujito, O. Samura, and Y. Kudo, “Plasma mRNA concentrations of placenta-specific 1 (PLAC1) and pregnancy associated plasma protein A (PAPP-A) are higher in early-onset than late-onset pre-eclampsia,” Journal of Obstetrics and Gynaecology Research, vol. 37, no. 4, pp. 313–318, 2011. View at Publisher · View at Google Scholar · View at Scopus
  25. M. Matteo, P. Greco, P. E. L. Setti et al., “Preliminary evidence for high anti-PLAC1 antibody levels in infertile patients with repeated unexplained implantation failure,” Placenta, vol. 34, no. 4, pp. 335–339, 2013. View at Publisher · View at Google Scholar
  26. A. C. Kotto-Kome, C. Silva, V. Whiteman, X. Kong, and M. E. Fant, “Circulating anti-PLAC1 antibodies during pregnancy and in women with reproductive failure: a preliminary analysis,” ISRN Immunology, vol. 2011, Article ID 530491, 5 pages, 2011. View at Publisher · View at Google Scholar
  27. Y. Chen, D. Schlessinger, and R. Nagaraja, “T antigen transformation reveals Tp53/RB-dependent route to PLAC1 transcription activation in primary fibroblasts,” Oncogenesis, vol. 2, article e67, 2013. View at Google Scholar