Figure 4: Effects of hypoxic ischemic brain injury and hUCB treatment on receptive field (RF) and cortical map size (see [28]). (a) In lesioned rats the size of the left cortical hindpaw (HP) representation was significantly reduced after hypoxic ischemic brain injury (HI) ( versus controls, versus contralateral hemisphere). Treatment with hUCB cells prevented map changes in the left cortical HP representation. (b)–(d) images of the cortical surface of the left hemisphere of a control (b), lesioned (c), and hUCB treated rat (d). Numbers indicate penetration sites; x indicates noncutaneous responses. hl: hindlimb. Borders of the maps are outlined. Scale bar 1 mm. (e) In lesioned rats RF size of the right HP was increased ( versus controls, versus HP ipsilateral to the lesion). hUCB treatment leads to moderate RF increase, not significantly different from controls ( ). Bars represent sem (f)–(h) examples of RFs on the right and left HP for a control (f), lesioned (g), and hUCB treated rat (h). Number of rats used: control group , lesion group , and hUCB group . A total of 975 RFs were recorded (left hemisphere: control 127: lesioned 97, treated 85; right hemisphere: control 192, lesioned 327, and treated 147). doi: 10.1371/journal.pone.0020194.g003. This paper is available online at: http://www.plosone.org/article/info:doi/10.1371/journal.pone.0020194.