Resveratrol, Acetyl-Resveratrol, and Polydatin Exhibit Antigrowth Activity against 3D Cell Aggregates of the SKOV-3 and OVCAR-8 Ovarian Cancer Cell Lines

Figure 2

Morphological appearance of SKOV-3 cell aggregates with and without treatment. At higher concentrations all three compounds gave aggregates with irregular rims. The effect was more prominent with resveratrol (d, e) and acetyl-resveratrol (i, j) than with polydatin (n, o). The smooth rims of cell aggregates treated with lower concentration were not visibly different from those of control aggregates. Resveratrol significantly reduced cell growth at 10, 50, and 100 μM (p), but acetyl-resveratrol (q) and polydatin (r) only affected growth activity at higher concentrations. refers to statistically significant as value less than 0.05 compared to the control.