Large D-Dimer Fluctuation in Normal Pregnancy: A Longitudinal Cohort Study of 4,117 Samples from 714 Healthy Danish Women

Table 2

The 95% D-dimer reference intervals during delivery and postpartum according to the mode of delivery.

	2.5th percentile; (90% CI)	97.5th percentile; (90% CI)	Samples ()	Outliers ()
Vaginal delivery
At delivery	0.7; (0.7–0.8)	7.5; (6.3–8.1)	443	10
1st day postpartum	0.8; (0.7–0.8)	11.7; (9.3–14.0)	438	1
2nd day postpartum	0.6; (0.6-0.6)	5.1; (4.3–9.6)	300	7
Scheduled cesarean
At delivery			36	2
1st day postpartum	0.9; (0.7–1.1)	8.5; (6.3–10)	60	1
2nd day postpartum	0.6; (0.6–0.8)	7.0; (3.9–7.7)	49	2
Emergency cesarean
At delivery	0.8; (0.8–1.0)	5.5; (4.0–5.5)	40	3
1st day postpartum	1.2; (1.2–1.5)	9.9; (9.3–9.9)	40	0
2nd day postpartum			35	0

D-dimer reference intervals in mg/L (FEU) for delivery and early postpartum period given as 2.5th and 97.5th percentiles (bold) with 90% confidence intervals (in brackets). For groups containing fewer than 40 samples, descriptive 5th and 95th percentiles are provided without any confidence intervals. Outliers were removed using Horn’s algorithm with a fence factor of 1.5.