White Matter Damage in 4,725 Term-Born Infants Is Determined by Head Circumference at Birth: The Missing Link

Table 4

Neonatal variables, Apgar scores, and acid-base balance as mean (SD) and 95% confidence intervals in morphometric index z-score bands of term-born neonates at 37–43 weeks gestation as compared with the reference (25 to <75%).

	Morphometric index (centile)	N	Mean	SD	95% confidence interval
					Lower limit	Upper limit
Apgar score_1′	<10%	471	8.41	1.38	8.28	8.53	<0.001
	10 to <25%	709	8.76	1.10	8.68	8.84	0.032
	25 to <75%	2,359	8.88	0.84	8.85	8.92	Reference
	75 to <90%	710	8.85	0.84	8.79	8.92	n.s.
	90 to <100%	470	8.79	0.90	8.70	8.87	n.s.
	Total	4,719	8.80	0.96	8.78	8.83
Apgar score_5′	<10%	470	9.55	0.95	9.46	9.63	<0.001
	10 to <25%	709	9.79	0.65	9.74	9.84	0.033
	25 to <75%	2,358	9.87	0.50	9.85	9.89	Reference
	75 to <90%	710	9.88	0.43	9.85	9.91	n.s.
	90 to <100%	470	9.81	0.63	9.76	9.87	n.s.
	Total	4,717	9.82	0.59	9.80	9.84
Apgar score_10′	<10%	471	9.83	0.59	9.78	9.89	<0.001
	10 to <25%	709	9.94	0.31	9.92	9.97	n.s.
	25 to <75%	2,360	9.97	0.23	9.96	9.98	Reference
	75 to <90%	710	9.97	0.20	9.96	9.99	n.s.
	90 to <100%	470	9.96	0.26	9.94	9.99	n.s.
	Total	4,720	9.95	0.30	9.94	9.96
pH, umbilical arterial blood (UAB)	<10%	466	7.27	0.09	7.26	7.28	<0.001
	10 to <25%	690	7.28	0.07	7.28	7.29	n.s.
	25 to <75%	2,318	7.29	0.07	7.28	7.29	Reference
	75 to <90%	701	7.28	0.06	7.28	7.29	n.s.
	90 to <100%	467	7.28	0.07	7.27	7.28	n.s.
	Total	4,642	7.28	0.07	7.28	7.28
pCO2 (UAB) (mmHF)	<10%	464	45.5	10.2	44.6	46.5	n.s.
	10 to <25%	688	44.2	8.2	43.6	44.8	n.s.
	25 to <75%	2,305	44.6	8.3	44.2	44.9	Reference
	75 to <90%	700	44.8	7.7	44.2	45.4	n.s.
	90 to <100%	462	45.9	8.0	45.2	46.6	0.015
	Total	4,619	44.8	8.4	44.5	45.0
Base excess (UAB) (mmol/L)	<10%	464	7.4	4.5	7.0	7.8	0.009
	10 to <25%	683	7.0	3.9	6.7	7.3	n.s.
	25 to <75%	2,297	6.7	3.7	6.6	6.9	Reference
	75 to <90%	696	7.0	3.9	6.7	7.3	n.s.
	90 to <100%	459	6.9	3.9	6.5	7.2	n.s.
	Total	4,599	6.9	3.9	6.8	7.0