White Matter Damage in 4,725 Term-Born Infants Is Determined by Head Circumference at Birth: The Missing Link

Table 5

Weeks gestation and growth variables as mean (SD) and 95% confidence intervals in morphometric index z-score bands of 4,725 term-born neonates at 37–43 weeks’ gestation as compared with the reference (25 to <75%).

	Morphometric index (centile)	N	Mean	SD	95% confidence interval
					Lower limit	Upper limit
Weeks gestation	<10%	472	38.67	1.4	38.5	38.8	<0.001
	10 to <25%	709	39.24	1.3	39.1	39.3	<0.001
	25 to <75%	2,362	40.00	1.1	40.0	40.0	Reference
	75 to <90%	710	40.39	1.0	40.3	40.5	<0.001
	90 to <100%	472	40.58	0.9	40.5	40.7	<0.001
	Total	4,725	39.87	1.3	39.8	39.9
Weight (g)	<10%	472	2,508	274	2,483	2,532	<0.001
	10 to <25%	709	2,951	136	2,941	2,961	<0.001
	25 to <75%	2,362	3,409	236	3,400	3,419	Reference
	75 to <90%	710	3,783	211	3,768	3,799	<0.001
	90 to <100%	472	4,211	280	4,186	4,236	<0.001
	Total	4,725	3,387	500	3,372	3,401
Length (cm)	<10%	472	47.4	2.0	47.2	47.6	<0.001
	10 to <25%	709	49.6	1.3	49.5	49.7	<0.001
	25 to <75%	2,362	51.6	1.6	51.5	51.6	Reference
	75 to <90%	710	53.2	1.6	53.1	53.3	<0.001
	90 to <100%	472	54.6	1.8	54.4	54.8	<0.001
	Total	4,725	51.4	2.5	51.3	51.5
Head circumference (cm)	<10%	472	32.9	1.3	32.8	33.1	<0.001
	10 to <25%	709	33.8	0.8	33.8	33.9	<0.001
	25 to <75%	2,362	34.8	0.9	34.7	34.8	Reference
	75 to <90%	710	36.1	0.6	36.1	36.2	<0.001
	90 to <100%	472	37.1	0.9	37.0	37.2	<0.001
	Total	4,725	34.9	1.4	34.8	34.9
Weight-length ratio (W/L)	<10%	472	52.89	5.07	52.43	53.34	<0.001
	10 to <25%	709	59.60	3.32	59.35	59.84	<0.001
	25 to <75%	2,362	66.13	4.31	65.95	66.30	Reference
	75 to <90%	710	71.16	4.05	70.87	71.46	<0.001
	90 to <100%	472	77.15	4.64	76.73	77.57	<0.001
	Total	4,725	65.68	7.60	65.46	65.90
PI (100^∗W/L³)	<10%	472	2.36	0.26	2.34	2.39	<0.001
	10 to <25%	709	2.44	0.23	2.42	2.45	<0.001
	25 to <75%	2,362	2.49	0.23	2.49	2.50	Reference
	75 to <90%	710	2.53	0.24	2.51	2.54	<0.001
	90 to <100%	472	2.60	0.24	2.58	2.62	<0.001
	Total	4,725	2.49	0.24	2.48	2.49