Assessment of Diagnostic Values among CA-125, RMI, HE4, and ROMA for Cancer Prediction in Women with Nonfunctional Ovarian Cysts

Table 2

Median, interquartile range, and range and diagnostic value of CA-125, RMI, HE4, and ROMA.

Tools	Median (P25-75)	Range	Sensitivity (%)	Specificity (%)	PPV	NPV
CA-125 (>35 IU/ml)	47.3 (22.1–141.9)	4.77–4,846	87.9	46.2	29.8	93.6
RMI (>250)	35.9 (0–185.5)	0–38,034	64	89.8	61	91
HE4 (>150 pMol/L)	39.7 (20.2–71.6)	27.2–1500	53.4	97.8	86.1	89
ROMA (premenopause)	13.9 (4.5–11.4)	0.9–99.7	66.67	88.52	48.78	94.19
ROMA (postmenopause)	43.9 (10.8–79.1)	2.4–99.4	88.89	70	66.67	90.92