Effect of Japanese Kampo Medicine Therapy for Menopausal Symptoms after Treatment of Gynecological Malignancy

Table 4

Change in symptoms.

Symptoms	Subitems of Kupperman Index	KKT group				KSS group
		n	Baseline	8 weeks		n	Baseline	8 weeks
Vasomotor symptoms	(1) Hot flash	13	2.2 ± 0.9	1.6 ± 1.1	0.16	12	2.3 ± 0.8	1.5 ± 1.0	0.046
	(2) Sweating	14	2.3 ± 0.6	2.1 ± 0.7	0.48	14	2.4 ± 0.7	1.6 ± 0.9	0.031
	(3) Sensitivity to cold	7	1.7 ± 0.8	1.3 ± 1.1	0.26	13	2.2 ± 0.8	1.8 ± 0.6	0.23
	(4) Dyspnea	6	1.8 ± 0.8	0.8 ± 1.0	0.084	11	1.7 ± 0.8	1.3 ± 0.9	0.16
Paresthesia	(5) Numbness extremities	7	1.3 ± 0.5	0.7 ± 0.8	0.16	9	1.7 ± 0.5	1.2 ± 1.0	0.23
	(6) Insensitive extremities	2	1.5 ± 0.7	0.5 ± 0.7	0.16	10	1.3 ± 0.5	0.9 ± 0.9	0.21
Insomnia	(7) Difficulty falling asleep	12	2.1 ± 0.8	1.6 ± 1.0	0.058	9	1.9 ± 0.8	1.4 ± 0.9	0.16
	(8) Not deepened sleep	13	2.2 ± 0.8	1.5 ± 1.0	0.033	11	2.3 ± 0.5	1.6 ± 0.9	0.020
Nervousness	(9) Excitable	10	1.3 ± 0.5	0.8 ± 0.8	0.096	8	1.4 ± 0.7	0.9 ± 1.0	0.10
	(10) Nervous	12	1.6 ± 0.7	1.4 ± 1.0	0.53	11	1.9 ± 0.8	1.8 ± 0.9	0.74
Melancholia	(11) Depressive mood	11	1.7 ± 0.6	1.5 ± 0.9	0.37	11	1.9 ± 0.9	1.4 ± 0.9	0.13
Vertigo	(12) Dizziness and nausea	8	1.6 ± 0.7	0.5 ± 0.8	0.034	10	1.2 ± 0.4	0.3 ± 0.5	0.007
Weakness	(13) Fatigability	13	2.0 ± 0.7	2.1 ± 0.8	0.065	13	2.5 ± 0.5	2.0 ± 0.9	0.059
Arthralgia and myalgia	(14) Stiff shoulder/back and joint pain	11	1.8 ± 0.9	2.1 ± 0.9	0.32	14	2.5 ± 0.7	1.9 ± 1.2	0.038
Headaches	(15) Headache	10	1.7 ± 0.7	1.0 ± 1.2	0.17	8	1.9 ± 0.8	1.5 ± 1.2	0.41
Palpitation	(16) Heart palpitation	7	2.4 ± 0.8	1.6 ± 1.0	0.033	12	1.4 ± 0.7	0.8 ± 0.6	0.011
Formication	(17) Formication (itchy skin)	0	—	—	—	2	1.5 ± 0.7	1.0 ± 1.4	0.065

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