Succinate-Based Dietary Supplement for Menopausal Symptoms: A Pooled Analysis of Two Identical Randomized, Double-Blind, Placebo-Controlled Clinical Trials
Table 3
Greene Climacteric Scale results.
Group
n
Number (%) of women with symptoms
Before treatment
After treatment
1. Heart palpitation
Supplement
114
80 (70.1%)
55 (48.2%)
0.0008
Placebo
113
76 (67.3%)
76 (67.3%)
0.7194
0.2980
0.0215
2. Feeling tense or nervous
Supplement
114
92 (80.7%)
86 (75.4%)
0.0003
Placebo
113
90 (79.6%)
91 (80.5%)
0.9655
0.9811
0.0012
3. Difficulty sleeping
Supplement
114
98 (85.9%)
52 (45.6%)
≤0.001
Placebo
113
82 (72.6%)
91 (80.5%)
0.0067
0.0007
≤0.001
4. Increased excitability
Supplement
114
86 (75.4%)
55 (48.2%)
≤0.001
Placebo
113
82 (72.6%)
83 (73.5%)
0.8861
0.6274
≤0.001
5. Panic attacks
Supplement
114
41 (36.0%)
27 (23.7%)
0.0433
Placebo
113
35 (31.0%)
30 (26.5%)
0.6298
0.8248
0.2745
6. Difficulty concentrating
Supplement
114
82 (71.9%)
35 (30.7%)
≤0.001
Placebo
113
72 (63.7%)
85 (75.2%)
0.2535
0.4192
≤0.001
7. Feeling tired or lacking energy
Supplement
114
106 (93.0%)
54 (47.4%)
≤0.001
Placebo
113
101 (89.4%)
105 (93.0%)
0.0490
0.0767
≤0.001
8. Loss of interest in most things
Supplement
114
69 (60.5%)
35 (30.7%)
≤0.001
Placebo
113
52 (46.0%)
66 (58.4%)
0.2947
0.1277
≤0.001
9. Sadness or depression
Supplement
114
99 (86.8%)
40 (35.1%)
≤0.001
Placebo
113
77 (68.1%)
88 (78.1%)
0.0087
0.0043
≤0.001
10. Crying spells
Supplement
114
63 (55.3%)
44 (38.6%)
0.0012
Placebo
113
62 (55.0%)
63 (55.8%)
0.7053
0.9988
0.0080
11. Irritability
Supplement
114
104 (91.2%)
50 (44.0%)
≤0.001
Placebo
113
92 (81.4%)
98 (86.7%)
0.0709
0.1970
≤0.001
12. Dizziness or fainting
Supplement
114
54 (47.4%)
40 (35.1%)
0.0196
Placebo
113
40 (35.4%)
35 (31.0%)
0.7467
0.3405
0.2626
13. Feeling pressure or tightness in the head or other body parts
Supplement
114
73 (64.0%)
46 (40.4%)
0.0010
Placebo
113
60 (53.1%)
57 (50.4%)
0.9535
0.4026
0.1534
14. Numbness or tingling in some body parts
Supplement
114
65 (57.0%)
54 (47.9%)
0.0748
Placebo
113
68 (60.2%)
65 (57.5%)
0.8573
0.4835
0.0327
15. Headaches
Supplement
114
99 (86.8%)
62 (54.4%)
≤0.001
Placebo
113
93 (82.3%)
93 (82.3%)
0.6250
0.04996
≤0.001
16. Muscle and joint pain
Supplement
114
97 (85.1%)
60 (52.6%)
≤0.001
Placebo
113
100 (88.5%)
91 (80.5%)
0.3175
0.0574
≤0.001
17. Numbness of hands and feet
Supplement
114
49 (43.0%)
41 (36.0%)
0.4467
Placebo
113
42 (37.2%)
40 (35.4%)
0.8413
0.5336
0.7042
18. Difficulty breathing
Supplement
114
45 (39.5%)
35 (30.7%)
0.2542
Placebo
113
36 (32.0%)
37 (32.7%)
0.6667
0.6805
0.9836
19. Hot flashes
Supplement
114
101 (88.6%)
50 (44.0%)
≤0.001
Placebo
113
86 (76.1%)
91 (80.5%)
0.0137
0.0158
≤0.001
20. Night sweats
Supplement
114
92 (80.7%)
46 (40.4%)
≤0.001
Placebo
113
85 (75.2%)
87 (77.0%)
0.2737
0.4847
≤0.001
21. Lack of sex drive
Supplement
114
92 (80.7%)
39 (34.2%)
≤0.001
Placebo
113
76 (67.3%)
88 (78.0%)
0.1692
0.0089
≤0.001
Number of symptomatic subjects before and after treatment (those that marked that each symptom bothered them at least “a little” as per Greene Climacteric Scale). Bold numbers indicate statistically significant values.
