The Effectiveness of Aloe Vera on Relief of Irritation and Nipple Pain in Lactating Women: Systematic Review and Meta-Analysis

Table 1

Characteristics of studies included in the systematic review.

Author	Year	Location	Study	Participants	Sample	Intervention	Tools	Outcomes	value
Alamolhoda [14]	2019	Iran	RCT	Primiparous with breast soreness and irritation	G1= 55; G2= 55	Group 1= 0.5 ml Aloe vera gel/three times/Day; Group2: breast milk	Pain= visual analog scale; Irritation= store scale	Nipple pain, irritation, discharge follow up = 10, 14 days
Meng [25]	2015	China	RCT	Patients with puerperal milk stasis	G1= 50; G2= 52; G3= 50	G1 = breast massage with cactus + Aloe vera cold compress G2= Aloe vera cold compress G3= traditional breast massage	Pain= visual analog scale	Pain and hardness follow up = after the treatments
Eshgizade [26]	2016	Iran	RCT	Patients with nipple fissure	G1= 30 G2= 30 G3= 30	G1= 0.5 ml olive oil; G2= 0.5 ml Aloe vera extract + 3–4 drop breast milk/3 times/day; G3= 3–4 drop breast milk	Pain= visual analog scale; Irritation= store scale	Pain and intensity of breast fissure follow up = 3, 7 days
Sari [23]	2021	Indonesia	Quasi-experimental	Patient with breast engorgement	G1= 17; G2= 17	G1= Aloe vera cold compress; G2= control	Pain= visual analog scale	Pain follow up = after the treatments
Susanti [24]	2017	Indonesia	Quasi-experimental	Patient with breast engorgement	G1= 16; G= 16	G1= Aloe vera cold compress; G2= control	Pain= visual analog scale	Pain follow up = after the treatments
Tafazoli [4]	2009	Iran	RCT	Patient with breast soreness and irritation	G1= 50; G1= 50	G1= Aloe vera gel/three times/day; G2= lanolin	Store scale = irritation = store scale	Irritation, follow up = 3, 7 days
Saeidi [27]	2015	Iran	RCT	Patient with breast soreness and irritation	G1= 50; G1= 50	G1 = Aloe vera gel/three times/day; G2= lanolin	Store scale = irritation = store scale	Irritation, follow up = 3, 7 days