Obstetrics and Gynecology International

Research Article

Characteristics of Serum Lipid Metabolism among Women Complicated with Hypertensive Disorders in Pregnancy: A Retrospective Cohort Study in Mainland China

Table 3

Comparison of maternal serum lipid concentrations among women with PE, GH, and CH.


Gestational week (weeks)	Serum lipid	Total HDPs	PE	GH	CH
Gestational week (weeks)	Serum lipid	Total HDPs	PE	GH	CH	GH vs. PE	CH vs.PE

4–16	TC (mmol/L)	4.64 ± 0.80	4.65 ± 0.77	4.61 ± 0.83	4.73 ± 0.83	0.963	0.557
	TG (mmol/L)	1.51 ± 0.81	1.49 ± 0.73	1.50 ± 0.96	1.66 ± 0.68	1.000	0.012
	LDLC (mmol/L)	2.84 ± 0.67	2.86 ± 0.63	2.79 ± 0.71	2.91 ± 0.69	0.107	0.916
	HDLC (mmol/L)	1.42 ± 0.41	1.40 ± 0.41	1.43 ± 0.40	1.45 ± 0.40	0.191	0.243
	Apo-A (g/L)	1.55 ± 0.35	1.53 ± 0.35	1.56 ± 0.35	1.61 ± 0.36	0.222	0.004
	Apo-B (g/L)	0.84 ± 0.19	0.84 ± 0.18	0.82 ± 0.20	0.89 ± 0.20	0.155	0.001
	Apo-E (g/L)	42.81 ± 14.45	42.31 ± 13.69	42.84 ± 15.48	44.26 ± 14.00	1.000	0.726
	FFA (mmol/L)	0.58 ± 0.20	0.57 ± 0.20	0.58 ± 0.21	0.64 ± 0.20	1.000	<0.001
	sdLDL (mmol/L)	0.91 ± 0.32	0.92 ± 0.31	0.86 ± 0.30	1.01 ± 0.35	0.080	0.063
28–42	TC (mmol/L)	6.47 ± 1.37	6.49 ± 1.46	6.49 ± 1.30	6.31 ± 1.16	1.000	0.226
	TG (mmol/L)	4.28 ± 2.10	4.35 ± 2.06	4.16 ± 2.05	4.37 ± 2.43	0.236	1.000
	LDLC (mmol/L)	3.86 ± 1.09	3.90 ± 1.08	3.87 ± 1.10	3.66 ± 1.03	1.000	0.013
	HDLC (mmol/L)	1.73 ± 0.41	1.70 ± 0.40	1.78 ± 0.42	1.70 ± 0.39	<0.001	1.000
	Apo-A (g/L)	1.96 ± 0.34	1.94 ± 0.34	2.00 ± 0.34	1.99 ± 0.32	0.002	0.102
	Apo-B (g/L)	1.30 ± 0.30	1.31 ± 0.30	1.30 ± 0.30	1.28 ± 0.26	0.818	0.636
	Apo-E (g/L)	72.07 ± 30.41	72.12 ± 29.54	71.45 ± 32.17	73.39 ± 29.21	1.000	1.000
	FFA (mmol/L)	0.49 ± 0.21	0.49 ± 0.21	0.49 ± 0.21	0.50 ± 0.24	1.000	1.000
	sdLDL (mmol/L)	1.51 ± 0.49	1.55 ± 0.53	1.50 ± 0.48	1.42 ± 0.36	0.454	0.021

Difference^a	TC (mmol/L)	1.91 ± 1.21	1.94 ± 1.32	1.91 ± 1.06	1.73 ± 1.17	1.000	0.045
	TG (mmol/L)	3.39 ± 2.25	3.47 ± 2.22	3.28 ± 2.17	3.33 ± 2.58	0.295	1.000
	LDLC (mmol/L)	1.01 ± 0.97	1.05 ± 0.95	1.03 ± 0.98	0.78 ± 1.00	1.000	0.001
	HDLC (mmol/L)	0.30 ± 0.42	0.29 ± 0.43	0.32 ± 0.40	0.25 ± 0.39	0.699	0.539
	Apo-A (g/L)	0.43 ± 0.34	0.42 ± 0.35	0.45 ± 0.33	0.40 ± 0.34	0.623	1.000
	Apo-B (g/L)	0.49 ± 0.27	0.50 ± 0.28	0.49 ± 0.25	0.43 ± 0.29	1.000	0.003
	Apo-E (g/L)	34.84 ± 29.18	36.76 ± 29.17	34.40 ± 29.02	30.35 ± 29.35	1.000	0.228
	FFA (mmol/L)	−0.12 ± 0.30	−0.10 ± 0.30	−0.14 ± 0.29	−0.17 ± 0.28	0.096	0.008
	sdLDL (mmol/L)	0.56 ± 0.46	0.60 ± 0.47	0.60 ± 0.44	0.39 ± 0.42	1.000	0.001

Data were expressed as mean ± standard deviation (SD). was considered statistically significant. HDP: hypertensive disorder of pregnancy, PE: preeclampsia, GH: gestational hypertension, CH: chronic hypertension, TC: total cholesterol, TG: triglyceride, LDLC: low-density lipoprotein cholesterol, HDL: high-density lipoprotein cholesterol, Apo: apolipoprotein, FFA: free fatty acid, sdLDL: small dense LDLC, difference^a represent blood lipid values at weeks 28–42 of gestation minus the values at weeks 4–16 of gestation, and vs.: versus.