Oxidative Medicine and Cellular Longevity

Oxidative Medicine and Cellular Longevity / 2008 / Article

Open Access

Volume 1 |Article ID 890561 | https://doi.org/10.4161/oxim.1.1.6842

Kenneth Maiese, Zhao Zhong Chong, Yan Chen Shang, Jinling Hou, "Therapeutic Promise and Principles: Metabotropic Glutamate Receptors", Oxidative Medicine and Cellular Longevity, vol. 1, Article ID 890561, 14 pages, 2008. https://doi.org/10.4161/oxim.1.1.6842

Therapeutic Promise and Principles: Metabotropic Glutamate Receptors

Received21 Aug 2008
Revised26 Aug 2008
Accepted27 Aug 2008

Abstract

For a number of disease entities, oxidative stress becomes a significant factor in the etiology and progression of cell dysfunction and injury. Therapeutic strategies that can identify novel signal transduction pathways to ameliorate the toxic effects of oxidative stress may lead to new avenues of treatment for a spectrum of disorders that include diabetes, Alzheimer's disease, Parkinson's disease and immune system dysfunction. In this respect, metabotropic glutamate receptors (mGluRs) may offer exciting prospects for several disorders since these receptors can limit or prevent apoptotic cell injury as well as impact upon cellular development and function. Yet the role of mGluRs is complex in nature and may require specific mGluR modulation for a particular disease entity to maximize clinical efficacy and limit potential disability. Here we discuss the potential clinical translation of mGluRs and highlight the role of novel signal transduction pathways in the metabotropic glutamate system that may be vital for the clinical utility of mGluRs.

Copyright © 2008 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


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