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Oxidative Medicine and Cellular Longevity
Volume 2 (2009), Issue 2, Pages 68-72
http://dx.doi.org/10.4161/oxim.2.2.8160

Lipid Peroxidation and Antioxidant Status in Head and Neck Squamous Cell Carcinoma Patients

1Department of Biochemistry, Lucknow University, Lucknow, India
2Department of Radiotherapy, CSM Medical University, Lucknow, India

Received 15 January 2009; Revised 6 February 2009; Accepted 12 February 2009

Copyright © 2009 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Oxidative stress, a consequence of an imbalance between the formation and inactivation of reactive oxygen species, may be involved in the pathogenesis of many diseases including cancer. To evaluate the magnitude of oxidative stress, a study on the plasma levels of superoxide dismutase, total thiols, ascorbic acid and malondialdehyde (MDA) has been done in head and neck squamous cell carcinoma patients before the start of any oncological treatment and compared with healthy controls. The specific activity of superoxide dismutase in cancer patients is decreased significantly when compared to the control (p < 0.05). The total thiol and ascorbic acid levels are significantly reduced (p < 0.005) whereas MDA levels are significantly increased in the patients (p < 0.00005). Our findings show that the oxidative stress is elevated in cancer patients as evidenced by elevated levels of lipid peroxidation products and depletion of enzymatic and non-enzymatic antioxidants.