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Role of Peroxiredoxin III in the Pathogenesis of Pre-eclampsia as Evidenced in Mice
Lianqin Li
,1 Masuo Obinata,2 and Katsuyoshi Hori31Obstetrics and Gynecology Center, Tsinghua University Second Hospital, Beijing, China
2Department of Cell Biology, Sendai, Japan
3Department of Vascular Biology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan
Abstract
As a member of peroxiredoxin (Prx) family, PrxIII has been demonstrated to play an important role in scavenging intracellular reactive oxygen species (ROS). Since PrxIII knockout mice exhibited oxidative stress in placentas resembling pathophysiologic changes in placentas of human pre-eclampsia, we measured blood pressure through the carotid artery and detected oxidative status by western blotting in pregnant mice. We did not notice hypertension in pregnant PrxIII knockout mice as compared with wild-type littermates, although endothelin-1 was overexpressed in PrxIII-deficient placentas. Our results indicate that PrxIII is not involved in pre-eclamptic development. Instead, PrxIII is an indispensable antioxidant in placentas where oxidative stress exists.
Copyright
Copyright © 2010 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
