Oxidative Medicine and Cellular Longevity

Oxidative Medicine and Cellular Longevity / 2010 / Article

Open Access

Volume 3 |Article ID 870507 | https://doi.org/10.4161/oxim.3.3.12070

Saša Raicevic, Dejan Cubrilo, Slobodan Arsenijevic, Gordana Vukcevic, Vladimir Živkovic, Milena Vuletic, Nevena Barudžic, Nebojša Andjelkovic, Olga Antonovic, Vladimir Jakovljevic, "Oxidative Stress in Fetal Distress: Potential Prospects for Diagnosis", Oxidative Medicine and Cellular Longevity, vol. 3, Article ID 870507, 5 pages, 2010. https://doi.org/10.4161/oxim.3.3.12070

Oxidative Stress in Fetal Distress: Potential Prospects for Diagnosis

Received01 Apr 2010
Revised13 Apr 2010
Accepted14 Apr 2010


Our aim was to investigate the relation between fetal distress and oxidative stress. Fetal distress was associated with increased concentration of superoxide in the fetal blood and with significant increase of the level of H2O2 in both maternal and fetal blood. The activity of superoxide dismutase was increased roughly sixfold (p < 0.01) in the maternal [7330 ± 2240 U/g of hemoglobin in controls (C) and 36811 ± 16862 U/g in fetal distress (FD)] and fetal blood (C: 5930 ± 2641 U/g; FD: 41912 ± 17133 U/g). In contrast, fetal distress was related to a considerable decrease of catalase activity in both maternal (C: 26011 ± 8811 U/g; FD: 7212 ± 1270 U/g) and fetal blood (C: 37194 ± 9191 U/g; FD: 6173 ± 1965 U/g). From this we concluded that in fetal distress, the maternal and fetal bloods are exposed to superoxide- and H2O2-mediated oxidative stress, which could be initiated by hypoxic conditions in the fetal blood and placenta. A tremendous increase/decrease of the activities of superoxide dismutase/catalase in the blood of women bearing a distressed fetus in comparison to healthy subjects implies that the assessment of superoxide dismutase/catalase activity could be of use for establishing a timely and accurate ante- or intrapartum diagnosis of fetal distress.

Copyright © 2010 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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