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Oxidative Medicine and Cellular Longevity
Volume 2011, Article ID 143269, 5 pages
http://dx.doi.org/10.1155/2011/143269
Review Article

Targeting HDACs: A Promising Therapy for Alzheimer's Disease

1College of Life Science, Capital Normal University, Beijing 100048, China
2College of Arts and Science, Beijing Union University, Beijing 100191, China
3Department of Physiology and Pathophysiology, Peking University School of Basic Medical Sciences, Beijing 100191, China
4Beijing Key Laboratory of Bioactive Substances and Functional Foods, Beijing Union University, Beijing 100191, China

Received 16 May 2011; Revised 22 July 2011; Accepted 23 July 2011

Academic Editor: Florian Lang

Copyright © 2011 Ke Xu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. J. Hardy, “A hundred years of Alzheimer's disease research,” Neuron, vol. 52, no. 1, pp. 3–13, 2006. View at Publisher · View at Google Scholar · View at Scopus
  2. J. Hardy and D. J. Selkoe, “The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics,” Science, vol. 297, no. 5580, pp. 353–356, 2002. View at Publisher · View at Google Scholar · View at Scopus
  3. J. A. Hardy and G. A. Higgins, “Alzheimer's disease: the amyloid cascade hypothesis,” Science, vol. 256, no. 5054, pp. 184–185, 1992. View at Google Scholar · View at Scopus
  4. L. M. Bekris, C. E. Yu, T. D. Bird, and D. W. Tsuang, “Genetics of Alzheimer disease,” Journal of Geriatric Psychiatry and Neurology, vol. 23, no. 4, pp. 213–227, 2010. View at Publisher · View at Google Scholar · View at Scopus
  5. E. Korzus, “Manipulating the brain with epigenetics,” Nature Neuroscience, vol. 13, no. 4, pp. 405–406, 2010. View at Publisher · View at Google Scholar · View at Scopus
  6. R. M. Stilling and A. Fischer, “The role of histone acetylation in age-associated memory impairment and Alzheimer's disease,” Neurobiology of Learning and Memory, vol. 96, no. 1, pp. 19–26, 2011. View at Publisher · View at Google Scholar
  7. S. E. Johnstone and S. B. Baylin, “Stress and the epigenetic landscape: a link to the pathobiology of human diseases?” Nature Reviews Genetics, vol. 11, no. 11, pp. 806–812, 2010. View at Publisher · View at Google Scholar · View at Scopus
  8. S. Y. Roth, J. M. Denu, and C. D. Allis, “Histone acetyltransferases,” Annual Review of Biochemistry, vol. 70, pp. 81–120, 2001. View at Publisher · View at Google Scholar · View at Scopus
  9. D. M. Chuang, Y. Leng, Z. Marinova, H. J. Kim, and C. T. Chiu, “Multiple roles of HDAC inhibition in neurodegenerative conditions,” Trends in Neurosciences, vol. 32, no. 11, pp. 591–601, 2009. View at Publisher · View at Google Scholar · View at Scopus
  10. N. Carey and N. B. la Thangue, “Histone deacetylase inhibitors: gathering pace,” Current Opinion in Pharmacology, vol. 6, no. 4, pp. 369–375, 2006. View at Publisher · View at Google Scholar · View at Scopus
  11. E. Michishita, J. Y. Park, J. M. Burneskis, J. C. Barrett, and I. Horikawa, “Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins,” Molecular Biology of the Cell, vol. 16, no. 10, pp. 4623–4635, 2005. View at Publisher · View at Google Scholar · View at Scopus
  12. A. J. de Ruijter, A. H. van Gennip, H. N. Caron, S. Kemp, and A. B. P. van Kuilenburg, “Histone deacetylases (HDACs): characterization of the classical HDAC family,” Biochemical Journal, vol. 370, no. 3, pp. 737–749, 2003. View at Publisher · View at Google Scholar · View at Scopus
  13. L. Gao, M. A. Cueto, F. Asselbergs, and P. Atadja, “Cloning and functional characterization of HDAC11, a novel member of the human histone deacetylase family,” Journal of Biological Chemistry, vol. 277, no. 28, pp. 25748–25755, 2002. View at Publisher · View at Google Scholar · View at Scopus
  14. K. N. Green, J. S. Steffan, H. Martinez-Coria et al., “Nicotinamide restores cognition in Alzheimer's disease transgenic mice via a mechanism involving sirtuin inhibition and selective reduction of Thr231-phosphotau,” Journal of Neuroscience, vol. 28, no. 45, pp. 11500–11510, 2008. View at Publisher · View at Google Scholar · View at Scopus
  15. Y. Su, J. Ryder, B. Li et al., “Lithium, a common drug for bipolar disorder treatment, regulates amyloid-β precursor protein processing,” Biochemistry, vol. 43, no. 22, pp. 6899–6908, 2004. View at Publisher · View at Google Scholar · View at Scopus
  16. H. Qing, G. He, P. T. T. Ly et al., “Valproic acid inhibits aβ production, neuritic plaque formation, and behavioral deficits in alzheimer's disease mouse models,” Journal of Experimental Medicine, vol. 205, no. 12, pp. 2781–2789, 2008. View at Publisher · View at Google Scholar · View at Scopus
  17. A. Ricobaraza, M. C. Tejedor, A. P. Mediavilla, D. Frechilla, J. del Río, and A. G. Osta, “Phenylbutyrate ameliorates cognitive deficit and reduces τ pathology in an alzheimer's disease mouse model,” Neuropsychopharmacology, vol. 34, no. 7, pp. 1721–1732, 2009. View at Publisher · View at Google Scholar · View at Scopus
  18. A. Ricobaraza, “Phenylbutyrate rescues dendritic spine loss associated with memory deficits in a mouse model of Alzheimer disease,” Hippocampus. In press. View at Publisher · View at Google Scholar
  19. H. Ding, P. J. Dolan, and G. V. Johnson, “Histone deacetylase 6 interacts with the microtubule-associated protein τ,” Journal of Neurochemistry, vol. 106, no. 5, pp. 2119–2130, 2008. View at Publisher · View at Google Scholar · View at Scopus
  20. O. Bruserud, C. Stapnes, E. Ersvær, B. T. Gjertsen, and A. Ryningen, “Histone deacetylase inhibitors in cancer treatment: a review of the clinical toxicity and the modulation of gene expression in cancer cell,” Current Pharmaceutical Biotechnology, vol. 8, no. 6, pp. 388–400, 2007. View at Publisher · View at Google Scholar · View at Scopus
  21. N. M. Tsankova, O. Berton, W. Renthal, A. Kumar, R. L. Neve, and E. J. Nestler, “Sustained hippocampal chromatin regulation in a mouse model of depression and antidepressant action,” Nature Neuroscience, vol. 9, no. 4, pp. 519–525, 2006. View at Publisher · View at Google Scholar · View at Scopus
  22. S. J. Haggarty, K. M. Koeller, J. C. Wong, C. M. Grozinger, and S. L. Schreiber, “Domain-selective small-molecule inhibitor of histone deacetylase 6 (HDAC6)-mediated tubulin deacetylation,” Proceedings of the National Academy of Sciences of the United States of America, vol. 100, no. 8, pp. 4389–4394, 2003. View at Publisher · View at Google Scholar · View at Scopus
  23. J. Trapp, R. Meier, D. Hongwiset, M. U. Kassack, W. Sippl, and M. Jung, “Structure-activity studies on suramin analogues as inhibitors of NAD+-dependent histone deacetylases (sirtuins),” ChemMedChem, vol. 2, no. 10, pp. 1419–1431, 2007. View at Publisher · View at Google Scholar · View at Scopus
  24. S. Peleg, F. Sananbenesi, A. Zovoilis et al., “Altered histone acetylation is associated with age-dependent memory impairment in mice,” Science, vol. 328, no. 5979, pp. 753–756, 2010. View at Publisher · View at Google Scholar · View at Scopus
  25. M. Kilgore, C. A. Miller, D. M. Fass et al., “Inhibitors of class 1 histone deacetylases reverse contextual memory deficits in a mouse model of alzheimer's disease,” Neuropsychopharmacology, vol. 35, no. 4, pp. 870–880, 2010. View at Publisher · View at Google Scholar · View at Scopus
  26. Y. I. Francis, M. Fà, H. Ashraf et al., “Dysregulation of histone acetylation in the APP/PS1 mouse model of Alzheimer's disease,” Journal of Alzheimer's Disease, vol. 18, no. 1, pp. 131–139, 2009. View at Publisher · View at Google Scholar · View at Scopus
  27. Z. Zhang, R. Zhao, J. Qi, S. Wen, Y. Tang, and D. Wang, “Inhibition of glycogen synthase kinase-3β by Angelica sinensis extract decreases β-amyloid-induced neurotoxicity and τ phosphorylation in cultured cortical neurons,” Journal of Neuroscience Research, vol. 89, no. 3, pp. 437–447, 2011. View at Publisher · View at Google Scholar
  28. J. Huang, Y. J. Chen, W. H. Bian, J. Yu, Y. W. Zhao, and X. Y. Liu, “Unilateral amyloid-β25-35 injection into the rat amygdala increases the expressions of aberrant τ phosphorylation kinases,” Chinese Medical Journal, vol. 123, no. 10, pp. 1311–1314, 2010. View at Publisher · View at Google Scholar · View at Scopus
  29. J. Gao, W. Y. Wang, Y. W. Mao et al., “A novel pathway regulates memory and plasticity via SIRT1 and miR-134,” Nature, vol. 466, no. 7310, pp. 1105–1109, 2010. View at Publisher · View at Google Scholar · View at Scopus
  30. C. Julien, C. Tremblay, V. Émond et al., “Sirtuin 1 reduction parallels the accumulation of τ in alzheimer disease,” Journal of Neuropathology and Experimental Neurology, vol. 68, no. 1, pp. 48–58, 2009. View at Publisher · View at Google Scholar · View at Scopus
  31. G. Donmez, D. Wang, D. E. Cohen, and L. Guarente, “SIRT1 suppresses β-amyloid production by activating the α-secretase gene ADAM10,” Cell, vol. 142, no. 2, pp. 320–332, 2010. View at Publisher · View at Google Scholar · View at Scopus
  32. D. M. Taylor, U. Balabadra, Z. Xiang et al., “A brain-permeable small molecule reduces neuronal cholesterol by inhibiting activity of sirtuin 2 deacetylase,” ACS Chemical Biology, vol. 6, no. 6, pp. 540–546, 2011. View at Publisher · View at Google Scholar
  33. Y. Kawamura, Y. Uchijima, N. Horike et al., “Sirt3 protects in vitro-fertilized mouse preimplantation embryos against oxidative stress-Induced p53-mediated developmental arrest,” Journal of Clinical Investigation, vol. 120, no. 8, pp. 2817–2828, 2010. View at Publisher · View at Google Scholar · View at Scopus
  34. S. H. Kim, H. F. Lu, and C. C. Alano, “Neuronal sirt3 protects against excitotoxic injury in mouse cortical neuron culture,” PLoS ONE, vol. 6, no. 3, 2011. View at Publisher · View at Google Scholar
  35. J. S. Guan, S. J. Haggarty, E. Giacometti et al., “HDAC2 negatively regulates memory formation and synaptic plasticity,” Nature, vol. 459, no. 7243, pp. 55–60, 2009. View at Publisher · View at Google Scholar · View at Scopus
  36. M. W. Akhtar, J. Raingo, E. D. Nelson et al., “Histone deacetylases 1 and 2 form a developmental switch that controls excitatory synapse maturation and function,” Journal of Neuroscience, vol. 29, no. 25, pp. 8288–8297, 2009. View at Publisher · View at Google Scholar · View at Scopus
  37. S. C. McQuown, R. M. Barrett, D. P. Matheos et al., “HDAC3 is a critical negative regulator of long-term memory formation,” Journal of Neuroscience, vol. 31, no. 2, pp. 764–774, 2011. View at Publisher · View at Google Scholar
  38. F. H. Bardai and S. R. d'Mello, “Selective toxicity by HDAC3 in neurons: regulation by Akt and GSK3β,” Journal of Neuroscience, vol. 31, no. 5, pp. 1746–1751, 2011. View at Publisher · View at Google Scholar
  39. Z. Zhao, H. Xu, and W. Gong, “Histone deacetylase 6 (HDAC6) is an independent deacetylase for α-tubulin,” Protein and Peptide Letters, vol. 17, no. 5, pp. 555–558, 2010. View at Publisher · View at Google Scholar · View at Scopus
  40. P. Bali, M. Pranpat, J. Bradner et al., “Inhibition of histone deacetylase 6 acetylates and disrupts the chaperone function of heat shock protein 90: a novel basis for antileukemia activity of histone deacetylase inhibitors,” Journal of Biological Chemistry, vol. 280, no. 29, pp. 26729–26734, 2005. View at Publisher · View at Google Scholar · View at Scopus
  41. S. Chen, G. C. Owens, H. Makarenkova, and D. B. Edelman, “HDAC6 regulates mitochondrial transport in hippocampal neurons,” PloS one, vol. 5, no. 5, 2010. View at Publisher · View at Google Scholar · View at Scopus
  42. M. A. Rivieccio, C. Brochier, D. E. Willis et al., “HDAC6 is a target for protection and regeneration following injury in the nervous system,” Proceedings of the National Academy of Sciences of the United States of America, vol. 106, no. 46, pp. 19599–19604, 2009. View at Publisher · View at Google Scholar · View at Scopus
  43. T. A. Bolger and T. P. Yao, “Intracellular trafficking of histone deacetylase 4 regulates neuronal cell death,” Journal of Neuroscience, vol. 25, no. 41, pp. 9544–9553, 2005. View at Publisher · View at Google Scholar · View at Scopus