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Oxidative Medicine and Cellular Longevity
Volume 2011 (2011), Article ID 160408, 8 pages
Research Article

Ameliorative Effects of Herbal Combinations in Hyperlipidemia

1BRD School of Biosciences, Sardar Patel University, Sardar Patel Maidan, Vadtal Road, Satellite Campus, P.O. Box 39, Vallabh Vidyanagar 388 120, India
2Spinal Cord and Brain Injury Research Center (SCoBIRC), University of Kentucky, Biomedical & Biological Sciences Research Building B0436-41, 741 S. Limestone St., Lexington, KY 40536, USA

Received 12 May 2011; Accepted 15 July 2011

Academic Editor: Gabriele Saretzki

Copyright © 2011 Nishant P. Visavadiya and A. V. R. L. Narasimhacharya. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The roots of Glycyrrhiza glabra, Withania somnifera, Asparagus racemosus, and Chlorophytum borivilianum and seeds of Sesamum indicum are ayurvedic medicinal plants used in India to treat several ailments. Our previous studies indicated that these plants possess hypolipidemic and antioxidant potential. The present study was aimed at investigating the composite effects of these plants on hypercholesterolemic rats. Three different combinations (5 gm%, given for four weeks) used in this study effectively reduced plasma and hepatic lipid profiles and increased fecal excretion of cholesterol, neutral sterol, and bile acid along with increasing the hepatic HMG-CoA reductase activity and bile acid content in hypercholesterolemic rats. Further, all three combinations also improved the hepatic antioxidant status (catalase, SOD, and ascorbic acid levels) and plasma total antioxidant capacity with reduced hepatic lipid peroxidation. Overall, combination I had the maximum effect on hypercholesterolemic rats followed by combinations II and III due to varying concentrations of the different classes of phytocomponents.