Oxidative Stress in Neurodegenerative Diseases: Mechanisms and Therapeutic Perspectives

Figure 5

Nrf2 regulates the expression of antioxidant enzymes. Under physiological conditions, Nrf2 binds to Keap1 and undergoes constitutive proteasome-dependent degradation. However, under oxidative stress, Keap1 changes its conformation and releases Nrf2, which moves to the nucleus and binds to ARE regulating the expression of several antioxidant enzymes.