Resveratrol Regulates Antioxidant Status, Inhibits Cytokine Expression and Restricts Apoptosis in Carbon Tetrachloride Induced Rat Hepatic Injury
Figure 5
Histological profile of representative liver tissue in experimental animals. (a) Normal control rat liver (group A). Arrow 1 indicates the normal structure of central vein with radially arranged hepatocytes around it. Arrow 2 indicates normal hepatocytes (H & E X 200); (b) CCl4 control (group B). Arrow 3 showed dilation of the central vein with few regenerative areas of hepatocytes around the central vein and distal part of liver. 4, 5 arrow showed extensive centrilobular necrosis around the central vein of liver (H & E X 200); (c) section from resveratrol (100 mg/kg) + CCl4 (group C) arrow 6 represents the magnitude of dilation of the central vein (H & E X 200); (d) section from resveratrol (200 mg/kg) + CCl4 ( group D) arrow 7 showed good protection of hepatocellular necrosis with a poorly dilated central vein and regular arrangement of hepatocytes around the central vein and also the distal part of the liver from the central vein along with a scattered regenerative zone of hepatocytes; very few necrotic zones were prominent showing hepatocytes maintaining nearnormal architecture (H & E X 200).
