Resveratrol Regulates Antioxidant Status, Inhibits Cytokine Expression and Restricts Apoptosis in Carbon Tetrachloride Induced Rat Hepatic Injury

Table 3

Effect of resveratrol on the size distribution and growth of hepatocyte nodules induced by CCl₄ in rats.

Groups	No. of rats with nodules	Nodules relative to size (% of total no.)		Mean nodular volume (cm^3)	Nodular volume/liver volume (%)
		<3–>1 mm	<1 mm
B	10	59 ± 7	41 ± 14	0.17 ± 0.04	1.3 ± 0.34
C	6	49 ± 15	51 ± 12	0.06 ± 0.02*	0.49 ± 0.14*
D	3	31 ± 12	69 ± 7	0.03 ± 0.05**	0.30 ± 0.22^**#

Group B, CCl₄-administered rats; group C, resveratrol-(100 mg/kg) treated rats; group D, resveratrol-(200 mg/kg) treated rats.
Results are mean ± S.E.M for 10 animals; One way ANOVA followed by Dunnett’s multiple comparison test.
^∗𝑃<0.05 and ^∗∗𝑃<0.01 as compared with group B.
^#𝑃<0.05 as compared with group C.
Animals from group A did not show any visible hepatocyte nodule.