Role of Reactive Oxygen Species in the Neural and Hormonal Regulation of the PNMT Gene in PC12 Cells

Figure 1

Effect of CoCl₂  and hypoxia exposure on free radicals. Levels of intracellular ROS (a) and extracellular NO (b) were measured in PC12 cells following 24 h exposure to either 200 μM CoCl₂ or 5% oxygen at 37°C. Data presented as relative fold change or NO concentration ± SEM from a minimum of three independent experiments. Significance defined as *𝑃<0.05; **𝑃<0.01.

(a) Intracellular ROS levels

(b) NO concentration