Assessment of Anti-Cytogenotoxic Effects of Quercetin in Animals Treated with Topotecan

Table 1

DNA strand breaks in bone marrow of mice after treatment with quercetin and/or topotecan (TPT) or cyclophosphamide (mean ± SD).

Treatment groups; (mg/kg)	Tail moment (arbitrary unit)	Tail DNA; (%)	Tail length; (μm )	Olive tail moment (arbitrary units)
Control	2.32 ± 0.40	6.78 ± 1.12	16.0 ± 4.84	5.18 ± 1.52
Quercetin (50)	2.68 ± 0.82	6.56 ± 1.67	14.4 ± 5.22	4.34 ± 0.89
Quercetin (100)	2.12 ± 0.35	6.62 ± 2.18	15.2 ± 5.40	3.40 ± 1.11
TPT (0.5)	7.12 ± 1.83**	18.2 ± 3.07**	35.0 ± 9.38*	12.4 ± 3.28*
Quercetin (50) + TPT (0.5)	3.98 ± 1.29^a	10.2 ± 1.95^b	24.4 ± 5.22	7.02 ± 1.53^a
Quercetin (100) + TPT (0.5)	2.64 ± 0.82^b	7.9 0 ± 2.57^b	16.8 ± 4.32^b	5.12 ± 1.66^b
TPT (1)	13.2 ± 2.27**	22.5 ± 4.42**	50.0 ± 6.44**	18.0 ± 2.51*
Quercetin (50) + TPT (1)	9.54 ± 1.82	14.6 ± 3.54^a	37.6 ± 4.27^a	10.9 ± 3.4^a
Quercetin (100) + TPT (1)	4.28 ± 1.52^b	11.3 ± 3.90^b	22.8 ± 6.72^b	6.88 ± 1.25^b
Cyclophosphamide 40	23.9 ± 4.57^#	26.0 ± 6.17^#	64.2 ± 6.76^#	14.58 ± 1.93^#

^∗𝑃<0.05 and ^∗∗𝑃<0.01 versus control (Kruskal-Wallis test followed by Dunn’s multiple comparisons test). ^a𝑃<0.05 and ^b𝑃<0.01 versus the corresponding TPT alone; ^#𝑃<0.01 versus control (Mann-Whitney U test).