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Oxidative Medicine and Cellular Longevity
Volume 2011, Article ID 918312, 11 pages
http://dx.doi.org/10.1155/2011/918312
Research Article

von Willebrand Factor and Oxidative Stress Parameters in Acute Coronary Syndromes

1Health Centre, 32 300 Gornji Milanovac, Serbia
2Department of Physiology, Faculty of Medicine, University of Kragujevac, 34 000 Kragujevac, Serbia
3Institute of Physiology “Richard Burian”, School of Medicine, University of Belgrade, 11 000 Belgrade, Serbia
4University Hospital Centre “Kragujevac” and Faculty of Medicine, University of Kragujevac, 34 000 Kragujevac, Serbia

Received 17 February 2011; Accepted 7 June 2011

Academic Editor: Kenneth Maiese

Copyright © 2011 Zoran Koprivica et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Considering the role of von Willebrand factor (vWf) in hemostasis, and the role of oxidative stress in the development of endothelial dysfunction and atherosclerotic disease, the aim of our study was to investigate the relationship between vWf, parameters of oxidative stress and different types of acute coronary syndromes (ACS). Levels of vWf activity (vWfAct), vWf antigen (vWfAg), nitric oxide (estimated through nitrites–NO2), superoxide anion radical (O2), hydrogen peroxide (H2O2), index of lipid peroxidation (estimated through thiobarbituric acid reactive substances–TBARS), superoxide dismutase (SOD) and catalase (CAT) activity of 115 patients were compared with those of 40 healthy controls. ACS patients had significantly higher vWfAct and vWfAg levels, as well as TBARS levels, while their levels of NO2, H2O2, SOD and CAT activities were lower than controls'. vWfAg showed high specificity and sensitivity as a test to reveal healthy or diseased subjects. Multivariant logistic regression marked only vWfAg and TBARS as parameters that were under independent effect of ACS type. The results of our study support the implementation of vWf in clinical rutine and into therapeutic targets, and suggest that ACS patients are in need of antioxidant supplementation to improve their impaired antioxidant defence.