Intensification of Doxorubicin-Related Oxidative Stress in the Heart by Hypothyroidism Is Not Related to the Expression of Cytochrome P450 NADPH-Reductase and Inducible Nitric Oxide Synthase, As Well As Activity of Xanthine Oxidase

<table class="table-group" id="tab1"><tr><td><table class="table"><tr><td class="thead-hr" colspan="4"><hr/></td></tr><tr class="thead"><td align="left"> </td><td align="center"> </td><td align="center">Methimazole (%)</td><td align="center"> </td></tr><tr class="thead"><td align="left"> </td><td align="center">0.000</td><td align="center">0.001 (MET<sub>L</sub>)</td><td align="center">0.025 (MET<sub>H</sub>)</td></tr><tr><td class="thead-hr" colspan="4"><hr/></td></tr><tr><td align="left">FT4</td><td align="center"><span style="width: 80.287498px;"><svg height="12.05" id="M11" style="vertical-align:-1.09097pt" version="1.1" viewbox="0 0 80.287498 12.05" width="80.287498" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,12.05)">
<g transform="translate(72,-62.36)">
<text transform="matrix(1,0,0,-1,-71.95,63.5)">
<tspan style="font-size: 12.50px; " x="0" y="0">1</tspan>
<tspan style="font-size: 12.50px; " x="6.2515001" y="0">0</tspan>
<tspan style="font-size: 12.50px; " x="12.503" y="0">.</tspan>
<tspan style="font-size: 12.50px; " x="15.62875" y="0">4</tspan>
<tspan style="font-size: 12.50px; " x="21.880251" y="0">8</tspan>
<tspan style="font-size: 12.50px; " x="30.907415" y="0">±</tspan>
<tspan style="font-size: 12.50px; " x="42.247639" y="0">1</tspan>
<tspan style="font-size: 12.50px; " x="48.499138" y="0">.</tspan>
<tspan style="font-size: 12.50px; " x="51.624886" y="0">1</tspan>
<tspan style="font-size: 12.50px; " x="57.876389" y="0">2</tspan>
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</g>
</g>
</svg></span></td><td align="center"><svg height="12.2375" id="M12" style="vertical-align:-1.09097pt" version="1.1" viewbox="0 0 72.474998 12.2375" width="72.474998" xmlns="http://www.w3.org/2000/svg">
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<g transform="translate(72,-62.21)">
<text transform="matrix(1,0,0,-1,-71.95,63.35)">
<tspan style="font-size: 12.50px; " x="0" y="0">6</tspan>
<tspan style="font-size: 12.50px; " x="6.2515001" y="0">.</tspan>
<tspan style="font-size: 12.50px; " x="9.3772497" y="0">1</tspan>
<tspan style="font-size: 12.50px; " x="15.62875" y="0">0</tspan>
<tspan style="font-size: 12.50px; " x="24.655916" y="0">±</tspan>
<tspan style="font-size: 12.50px; " x="35.996136" y="0">1</tspan>
<tspan style="font-size: 12.50px; " x="42.247639" y="0">.</tspan>
<tspan style="font-size: 12.50px; " x="45.373386" y="0">5</tspan>
<tspan style="font-size: 12.50px; " x="51.624886" y="0">5</tspan>
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<tspan style="font-size: 12.50px; " x="10.890113" y="0">=</tspan>
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<tspan style="font-size: 12.50px; " x="29.182001" y="0">.</tspan>
<tspan style="font-size: 12.50px; " x="32.307751" y="0">0</tspan>
<tspan style="font-size: 12.50px; " x="38.559254" y="0">0</tspan>
<tspan style="font-size: 12.50px; " x="44.810753" y="0">0</tspan>
<tspan style="font-size: 12.50px; " x="51.062252" y="0">9</tspan>
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</g>
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</svg>)</td><td align="center">Below limit of detection (&lt;2.60)</td></tr><tr><td align="left">FT3</td><td align="center"><span style="width: 72.474998px;"><svg height="12.2375" id="M14" style="vertical-align:-1.09097pt" version="1.1" viewbox="0 0 72.474998 12.2375" width="72.474998" xmlns="http://www.w3.org/2000/svg">
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<tspan style="font-size: 12.50px; " x="35.996136" y="0">0</tspan>
<tspan style="font-size: 12.50px; " x="42.247639" y="0">.</tspan>
<tspan style="font-size: 12.50px; " x="45.373386" y="0">4</tspan>
<tspan style="font-size: 12.50px; " x="51.624886" y="0">9</tspan>
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</svg></span></td><td align="center"><svg height="12.2375" id="M15" style="vertical-align:-1.09097pt" version="1.1" viewbox="0 0 72.474998 12.2375" width="72.474998" xmlns="http://www.w3.org/2000/svg">
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<tspan style="font-size: 12.50px; " x="9.3772497" y="0">3</tspan>
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<tspan style="font-size: 12.50px; " x="45.373386" y="0">5</tspan>
<tspan style="font-size: 12.50px; " x="51.624886" y="0">7</tspan>
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</svg> (<svg height="11.0375" id="M16" style="vertical-align:-0.27588pt" version="1.1" viewbox="0 0 71.775002 11.0375" width="71.775002" xmlns="http://www.w3.org/2000/svg">
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<tspan style="font-size: 12.50px; " x="0" y="0">𝑃</tspan>
<tspan style="font-size: 12.50px; " x="10.890113" y="0">=</tspan>
<tspan style="font-size: 12.50px; " x="22.930502" y="0">0</tspan>
<tspan style="font-size: 12.50px; " x="29.182001" y="0">.</tspan>
<tspan style="font-size: 12.50px; " x="32.307751" y="0">0</tspan>
<tspan style="font-size: 12.50px; " x="38.559254" y="0">0</tspan>
<tspan style="font-size: 12.50px; " x="44.810753" y="0">9</tspan>
<tspan style="font-size: 12.50px; " x="51.062252" y="0">2</tspan>
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</g>
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</svg>)</td><td align="center"> Below limit of detection (&lt;1.67)</td></tr><tr class="table-tr"><td colspan="4"><hr class="tbody-hr"/></td></tr></table></td></tr></table>

The concentration (pmol/L; <svg height="12.05" id="M10" style="vertical-align:-1.09097pt" version="1.1" viewbox="0 0 54 12.05" width="54" xmlns="http://www.w3.org/2000/svg">
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<tspan style="font-size: 12.50px; " x="12.653036" y="0">±</tspan>
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<tspan style="font-size: 12.50px; " x="30.944925" y="0">.</tspan>
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</svg>.) of free tetraiodothyronine (FT4) and triiodothyronine (FT3) in rats serum 48 h after withdrawal of methimazole.

Oxidative Medicine and Cellular Longevity

tab1

Table 1

Table 1: Intensification of Doxorubicin-Related Oxidative Stress in the Heart by Hypothyroidism Is Not Related to the Expression of Cytochrome P450 NADPH-Reductase and Inducible Nitric Oxide Synthase, As Well As Activity of Xanthine Oxidase 

Table 1 | Intensification of Doxorubicin-Related Oxidative Stress in the Heart by Hypothyroidism Is Not Related to the Expression of Cytochrome P450 NADPH-Reductase and Inducible Nitric Oxide Synthase, As Well As Activity of Xanthine Oxidase 