Intensification of Doxorubicin-Related Oxidative Stress in the Heart by Hypothyroidism Is Not Related to the Expression of Cytochrome P450 NADPH-Reductase and Inducible Nitric Oxide Synthase, As Well As Activity of Xanthine Oxidase

Table 3

Carbonyl group concentration (nmol/mg of of cardiac protein; 𝑋±S.D.) in rat cardiac homogenates 4, 48, and 96 h after doxorubicin administration.

Time from DOX injection (h)	DOX (mg/kg) or saline	Methimazole (%)			ANOVA
		0.0000	0.001 (METL)	0.025 (METH)	𝑃
4	2	19.55±5.12	28.18±6.11^*,#	45.45±16.15^*,#,†	0.0098
	5	19.41±9.41	38.65±13.45^*,#	103.08±46.03^*,#,†	0.0050
	15	57.52±16.05^*	20.08±7.59^#	75.77±14.25^*,#	0.0060
48	2	18.92±5.30	29.46±6.92^*,#	42.75±12.46^*,#	0.0098
	5	21.29±6.62	40.43±22.04^*,#	109.95±84.48^*,#	0.0063
	15	54.73 ± 1434^*	14.70±6.57^#	124.24±62.84^*,#	0.0045
96	2	15.39±4.24	28.49±10.61^*,#	37.21±6.67^*,#	0.0081
	5	15.05±4.30	19.51±4.37^#	89.22±42.42^*,#,†	0.0052
	15	39.30±10.14^*	15.06±4.98^#	91.76±56.76^*,#,†	0.0025
	0.9% NaCl	𝟏𝟕.𝟔𝟖±𝟓.𝟗𝟐 (control)	17.87±3.35	20.87±4.29	—

^*𝑃<0.05 versus control; ^#DOX + MET versus DOX; ^†DOX + MET_H + versus DOX + MET_L.