Intensification of Doxorubicin-Related Oxidative Stress in the Heart by Hypothyroidism Is Not Related to the Expression of Cytochrome P450 NADPH-Reductase and Inducible Nitric Oxide Synthase, As Well As Activity of Xanthine Oxidase

Table 5

Total glutathione concentration (nmol/g of cardiac sample; 𝑋±S.D.) in rat cardiac homogenates 4, 48, and 96 h after doxorubicin administration.

Time from DOX injection (h)	DOX (mg/kg) or saline	Methimazole (%)			ANOVA
		0.0000	0.001 (METL)	0.025 (METH)	𝑃
4	2	369.27±29.45	353.04±30.24	363.68±37.97	0.6505
	5	405.83±77.76	356.66±26.28	394.16±39.15	0.3356
	15	348.33±22.55	418.33±52.50	363.33±39.46	0.0514
48	2	361.54±43.76	395.52±31.92	378.85±29.82	0.4449
	5	353.33±70.73	454.16±46.68^*,#	455.83±41.10^*,#	0.0418
	15	395.83±69.53	564.16±72.08^*,#	439.17±16.82^*,#,†	0.0080
96	2	339.16±43.16	328.33±27.54	362.50±35.84	0.2101
	5	340.00±31.54	421.66±49.07^*	300.83±62.04^*,#,†	0.0081
	15	322.92±55.54	367.71±34.42	365.00±38.14	0.3813
	0.9% NaCl	𝟑𝟔𝟖.𝟑𝟑±𝟑𝟒.𝟒𝟑 (control)	342.71±83.57	395.83±25.68	—

^*𝑃<0.05 versus control; ^#DOX + MET versus DOX; ^†DOX + MET_H versus DOX + MET_L.