Bisphenol A Induces Hepatotoxicity through Oxidative Stress in Rat Model

Table 5

The effect of BPA on antioxidant enzymes, GSHPx, CAT, GR, and GST activity on rat liver tissues.

Treatment groups	GSHPx (𝜇mol/g wet tissue)	CAT (𝜇mol/min/g tissue)	GR (ng/mL)	GST (𝜇mol/min/g tissue)
Control	204.2 ± 11.1	86.1 ± 0.34	1.09 ± 0.02	37.2 ± 0.5
BPA 0.1 mg/kg	200 ± 0.8	84.4 ± 0.22	0.97 ± 0.01	36.8 ± 0.7
BPA 1 mg/kg	197.5 ± 1.5	77.4 ± 0.40	0.91 ± 0.01	35.9 ± 0.9
BPA 10 mg/kg	174.6 ± 0.29	72.2 ± 0.32	0.88 ± 0.06	30.7 ± 1.08
BPA 50 mg/kg	50.6 ± 1.4^*	29.5 ± 0.32^*	0.3 ± 0.09^*	16.2 ± 0.8^*

Effect of BPA on the activity of the antioxidant enzymes, glutathione peroxidase (GSHPx), catalase (CAT), glutathione transferase (GST), and glutathione reductase (GR) in liver tissues. Data are presented as the mean ± SEM.
^*Indicate significant change from control, at 𝑃<0.05 using ANOVA followed by Tukey-Kramer as a post-ANOVA test.