Oxidative Medicine and Cellular Longevity

Research Article

Coffee Polyphenols Change the Expression of STAT5B and ATF-2 Modifying Cyclin D1 Levels in Cancer Cells

Table 5

List of underexpressed genes in HT29 cells upon incubation with caffeic acid.


Gene symbol	Gene title	value	FC absolute	Regulation

MFSD7	Major facilitator superfamily domain containing 7	1.00E-04	1.3	Down
MSI2	Musashi homolog 2 (Drosophila)	0.027	1.3	Down
CDA	Cytidine deaminase	2.00E-04	1.31	Down
DEFB1	Defensin, beta 1	0.026	1.31	Down
PIP5K1A	Phosphatidylinositol-4-phosphate 5-kinase, type I, alpha	0.027	1.31	Down
ZDHHC20	Zinc finger, DHHC-type containing 20	0.005	1.31	Down
ZDHHC21	Zinc finger, DHHC-type containing 21	0.016	1.31	Down
SLC4A7	Solute carrier family 4, member 7	0.0249	1.32	Down
CEACAM1	Carcinoembryonic antigen-related cell adhesion molecule 1	0.0459	1.32	Down
PDZRN3	PDZ domain containing RING finger 3	0.002	1.32	Down
WDR62	WD repeat domain 62	0.005	1.32	Down
FAM76B	Family with sequence similarity 76, member B	0.036	1.32	Down
TCF21	Transcription factor 21	0.029	1.33	Down
TBL1XR1	Transducin (beta)-like 1 X-linked receptor 1	6.00E-04	1.33	Down
CLK4	CDC-like kinase 4	0.021	1.33	Down
CYP2A13	Cytochrome P450, family 2, subfamily A, polypeptide 13	0.009	1.34	Down
CXCR4	Chemokine (C-X-C motif) receptor 4	0.0488	1.34	Down
ATF2	Activating transcription factor 2	0.0158	1.35	Down
PDE10A	Phosphodiesterase 10A	0.03	1.35	Down
METT10D	Methyltransferase 10 domain containing	0.003	1.35	Down
PRMT2	Protein arginine methyltransferase 2	7.00E-04	1.36	Down
GLS	Glutaminase	5.70E-04	1.37	Down
SLC38A5	Solute carrier family 38, member 5	0.043	1.37	Down
TINAG	Tubulointerstitial nephritis antigen	0.043	1.38	Down
AQP1	Aquaporin 1 (Colton blood group)	0.0221	1.4	Down
JMJD6	Jumonji domain containing 6	0.004	1.4	Down
SAP30L	SAP30-like	0.021	1.4	Down
FGD4	FYVE, RhoGEF, and PH domain containing 4	0.026	1.52	Down
S100A2	S100 calcium-binding protein A2	0.005	1.53	Down
CTSZ	Cathepsin Z	0.045	1.53	Down
SLC4A4	Solute carrier family 4, member 4	9.00E-04	1.54	Down
AGR3	Anterior gradient homolog 3 (Xenopus laevis)	0.011	1.69	Down

The table shows the list of underexpressed genes by 1.3-fold with a value obtained in cells treated with caffeic acid and includes the gene symbol for all genes, their associated description. The ratio columns correspond to the absolute fold change in expression relative to the control group and the type of regulation (down: downregulation).