Gliclazide Does Not Fully Prevent 2-Deoxy-D-Ribose-Induced Oxidative Damage Because It Does Not Restore Glutathione Content in a Pancreatic β-Cell Line
Figure 5
Effects of gliclazide and NAC on the dRib-induced depletion of intracellular glutathione. The intracellular glutathione levels were determined by measuring the fluorescent intensity of the GSH-mBCl adduct (a) or using a glutathione assay kit (b). Experimental conditions were as described in the Section 2. These experiments were performed twice in quadruplicate. * and ** versus control treated with vehicle alone (0.04% DMSO). †† versus 35 mM dRib group evaluated by one-way ANOVA with Duncan’s post hoc test.
