Metformin Rescues the Myocardium from Doxorubicin-Induced Energy Starvation and Mitochondrial Damage in Rats

Figure 1

MET protects the myocardium against DOX-induced energy starvation. Rats (𝑛=10/per treatment type) received normal saline, DOX in a total cumulative dose of 18 mg/kg, MET (50 or 500 mg/kg, p.o., daily), or DOX plus either dose of MET. 24 h after receiving the last dose of DOX, ATP was determined in heart tissues using HPLC. Data are presented as mean ± SEM (𝑛=10). * and # indicate significant change from control and DOX, respectively, at 𝑃<0.05 using ANOVA followed by the Tukey-Kramer as a post-ANOVA test.