Metformin Rescues the Myocardium from Doxorubicin-Induced Energy Starvation and Mitochondrial Damage in Rats

Figure 3

MET protects myocardium against DOX-induced histopathological deteriorations. Photos (i) A and B show normal cardiac structure derived from normal control rat. Photos (ii) A and B are derived from heart section of a rat treated with a total cumulative dose of 18 mg/kg DOX and shows myocardial fiber injury as vacuolar changes of the cytoplasm and inflammatory infiltrate consisting of lymphocytes, plasma cells and histiocytes (arrow). Photos (iii) A and B show heart sections derived from a rat treated with MET 50 mg/kg prior to a total cumulative dose of 18 mg/kg DOX. It shows few inflammatory foci with considerable improvement in heart histology. Photos (iv) A and B illustrate heart sections obtained from a rat pretreated with MET 500 mg/kg before a total cumulative dose of 18 mg/kg DOX, revealing almost normal histology with a marked improvement in heart histology. Magnification, 400x in A; 100x in B.