Riluzole-Triggered GSH Synthesis via Activation of Glutamate Transporters to Antagonize Methylmercury-Induced Oxidative Stress in Rat Cerebral Cortex

Table 1

Effects of MeHg exposure and riluzole pretreatment on Hg, MDA, sulfydryl, and carbonyl levels.

Groups	Hg (μg·g^−1)	MDA (nmol·mg^−1·pro)	Sulfydryl (μmol·g^−1·pro)	carbonyl (nmol·mg^−1·pro)
Control	1.15±0.24	2.30±0.16	46.19±6.86	2.57±0.46
Riluzole	1.07±0.26	2.46±0.56	48.17±6.99	2.80±0.75
MeHg	15.05±2.73^**	3.85±0.55^**	33.21±4.12^**	6.15±1.35^**
Riluzole + MeHg	13.75±1.95^**	2.31±0.17^##	38.93±6.21^*#	5.13±1.09^**#

Data are mean ± SD, 𝑛=6 each.
^∗𝑃<0.05, ^**𝑃<0.01 denote statistical significance compared with control group.
^#𝑃<0.05, ^##𝑃<0.01 denote statistical significance compared with MeHg alone group.