The Role of Dietary Polyphenols on Adult Hippocampal Neurogenesis: Molecular Mechanisms and Behavioural Effects on Depression and Anxiety
Table 2
Effects of different polyphenolic-based diets or treatments on the expression of cell proliferation and differentiation markers, especially in the adult hippocampus.
In vivo: animals fed for 40 days with either a control diet or with LMN diet
In vivo: 129S1/SvImJ mice
In vivo: increased proliferation and differentiation in DG and SVZ
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In vitro: LMN cream (0.05, 0.10, 0.20, 0.30, 0.40, 0.50, 0.60,0.70, 0.80, and 1.00 mg/mL) for 24 h
In vitro: neuron-glial cell cultures (hippocampal and cortical) pretreated with
In vitro: cortical cells: antioxidant effect (approximately 80%) Hippocampal cells: antioxidant LMN range concentration restricted to 0.50 and 0.60 mg/mL; antioxidant capacity of approximately 100%
Increased neurogenesis and expression of hippocampal BDNF and pCREB as one of the molecular and cellular mechanisms underlying the antidepressant action of XBXT-2