Oxidative Medicine and Cellular Longevity / 2012 / Article / Tab 4

Review Article

Preclinical and Clinical Evidence of Antioxidant Effects of Antidepressant Agents: Implications for the Pathophysiology of Major Depressive Disorder

Table 4

Antidepressant treatment and oxidative stress markers in major depressive disorder.

Sample (F/M)Altered oxidative stress markers in MDaTreatment durationAntidepressant drugs testedEffect for antidepressantsReference

34/28 ↑MDA ↑SOD VitC4 weeks and 12 weeksCitalopram ( ), fluoxetine ( )MDA SOD ↑VitC (effects in both 4 and 12 weeks treatment)Khanzode et al., 2003 [27]
72/24↑MDA SOD TAC VitE6 weeksReboxetine, sertraline, venlafaxineNo effectsSarandol et al., 2007 [28]
19/17 XO SOD 8 weeksCitalopram ( ), fluoxetine ( ),XO ↑SOD nitrite
fluvoxamine ( ), sertraline ( )Herken et al., 2007 [29]
21/9 MDA SOD GPx GR12 weeksCitalopram ( ), fluoxetine ( ), fluvoxamine ( ), sertraline ( )MDA SOD GPx GRBilici et al., 2001 [30]
28/22 MDA SOD CAT TAC12 weeksFluoxetine ( )MDAGalecki et al., 2009 [48]
46/11 TAC TOS OSI12 weeksEscitalopram ( ), paroxetine ( ), sertraline ( )↑TAC TOS OSICumurcu et al., 2009 [32]
39/11 MDA OxLDL SOD24 weeksCitalopram ( ), escitalopram ( ), fluoxetine ( ), milnacipran ( ), moclobemide ( ), paroxetine ( ), sertraline ( ), tianeptine ( ), venlafaxine ( )MDA SOD TACKotan et al., 2011 [33]
20/15 CoQ10? weeks? ( )No effects*Maes et al., 2009 [34]
5/2 XOPost-mortem studySSRI ( ), TCA ( )No effects#Michel et al., 2010 [35]
6/9 GPx GSHPost-mortem studyTrazodone ( ), nefazodone ( , one together SSRI), TCA and/or SSRI ( )No effects#Gawryluk et al., 2011 [31]
GSTPost-mortem studyNo effects*Gawryluk et al., 2011 [36]

Sample (female/male) from MD group; aCompared to respective control group. *Compared to unmedicated MD group; #speculative. CAT, catalase; CoQ10, coenzyme Q-10; GPx, glutathione peroxidase; GSH, glutathione; GST, glutathione S-transferase; MDA, malondialdehyde; OSI, oxidative stress index; OxLDL, oxidized LDL; SOD, superoxide dismutase; SSRI, selective serotonin reuptake inhibitor; TAC, total antioxidant capacity; TCA, tricyclic or tetracyclic antidepressant; TOS, total oxidant status; VitC, vitamin C; VitE, vitamin E; XO, xanthine oxidase.

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