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Oxidative Medicine and Cellular Longevity
Volume 2012, Article ID 636419, 6 pages
http://dx.doi.org/10.1155/2012/636419
Research Article

Oxidative Damage, Inflammation, and Toll-Like Receptor 4 Pathway Are Increased in Preeclamptic Patients: A Case-Control Study

1Laboratório de Fisiopatologia Experimental and Instituto Nacional Translacional em Medicina (INCT-TM), Programa de Pós-Graduação em Ciências da Saúde, Unidade Acadêmica de Ciências da Saúde, Universidade do Extremo Sul Catarinense, Avenida Universitária, 1105, 88806-000 Criciúma, SC, Brazil
2Laboratory of Exercise Biochemistry and Physiology, Graduate Program in Health Sciences, University of Southern Santa Catarina-UNESC, Criciúma, SC, Brazil

Received 10 February 2012; Revised 24 April 2012; Accepted 7 May 2012

Academic Editor: Neelam Khaper

Copyright © 2012 Fabiana C. B. Bernardi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. S. A. Friedman, R. N. Taylor, and J. M. Roberts, “Pathophysiology of preeclampsia,” Clinics in Perinatology, vol. 18, no. 4, pp. 661–682, 1991. View at Google Scholar · View at Scopus
  2. A. M. Roggensack, Y. Zhang, and S. T. Davidge, “Evidence for peroxynitrite formation in the vasculature of women with preeclampsia,” Hypertension, vol. 33, no. 1 I, pp. 83–89, 1999. View at Google Scholar · View at Scopus
  3. F. Bernardi, F. Guolo, T. Bortolin, F. Petronilho, and F. Dal-Pizzol, “Oxidative stress and inflammatory markers in normal pregnancy and preeclampsia,” Journal of Obstetrics and Gynaecology Research, vol. 34, no. 6, pp. 948–951, 2008. View at Publisher · View at Google Scholar · View at Scopus
  4. J. Vanderlelie, K. Venardos, V. L. Clifton, N. M. Gude, F. M. Clarke, and A. V. Perkins, “Increased biological oxidation and reduced anti-oxidant enzyme activity in pre-eclamptic placentae,” Placenta, vol. 26, no. 1, pp. 53–58, 2005. View at Publisher · View at Google Scholar · View at Scopus
  5. Y. Wang, S. W. Walsh, and H. H. Kay, “Placental lipid peroxides and thromboxane are increased and prostacyclin is decreased in women with preeclampsia,” American Journal of Obstetrics and Gynecology, vol. 167, no. 4 I, pp. 946–949, 1992. View at Google Scholar · View at Scopus
  6. S. Zhao, Y. Gu, Q. Dong, R. Fan, and Y. Wang, “Altered interleukin-6 receptor, IL-6R and gp130, production and expression and decreased SOCS-3 expression in placentas from women with pre-eclampsia,” Placenta, vol. 29, no. 12, pp. 1024–1028, 2008. View at Publisher · View at Google Scholar · View at Scopus
  7. M. K. Yeon, R. Romero, Y. O. Seo et al., “Toll-like receptor 4: a potential link between 'danger signals,' the innate immune system, and preeclampsia?” American Journal of Obstetrics and Gynecology, vol. 193, no. 3, pp. 921–927, 2005. View at Publisher · View at Google Scholar · View at Scopus
  8. B. B. van Rijn, A. Franx, E. A. P. Steegers et al., “Maternal TLR4 and NOD2 gene variants, pro-inflammatory phenotype and susceptibility to early-onset preeclampsia and HELLP syndrome,” PLoS One, vol. 3, no. 4, Article ID e1865, 2008. View at Publisher · View at Google Scholar · View at Scopus
  9. A. Molvarec, M. Jermendy, M. Kovács et al., “Toll-like receptor 4 gene polymorphisms and preeclampsia: lack of assocaition in a Caucasian population,” Hypertension Research, vol. 31, no. 5, pp. 859–864, 2008. View at Publisher · View at Google Scholar · View at Scopus
  10. F. Xie, Y. Hu, S. E. Turvey et al., “Toll-like receptors 2 and 4 and the cryopyrin inflammasome in normal pregnancy and pre-eclampsia,” An International Journal of Obstetrics and Gynaecology, vol. 117, no. 1, pp. 99–108, 2010. View at Publisher · View at Google Scholar · View at Scopus
  11. C. W. G. Redman, G. P. Sacks, and I. L. Sargent, “Preeclampsia: an excessive maternal inflammatory response to pregnancy,” American Journal of Obstetrics and Gynecology, vol. 180, no. 2 I, pp. 499–506, 1999. View at Publisher · View at Google Scholar · View at Scopus
  12. Y. Jonsson, M. Rubèr, L. Matthiesen et al., “Cytokine mapping of sera from women with preeclampsia and normal pregnancies,” Journal of Reproductive Immunology, vol. 70, no. 1-2, pp. 83–91, 2006. View at Publisher · View at Google Scholar · View at Scopus
  13. G. M. Stirrat, “Pregnancy and immunity,” British Medical Journal, vol. 308, no. 6941, pp. 1385–1386, 1994. View at Google Scholar · View at Scopus
  14. T. G. Wegmann, H. Lin, L. Guilbert, and T. R. Mosmann, “Bidirectional cytokine interactions in the maternal-fetal relationship: is successful pregnancy a TH2 phenomenon?” Immunology Today, vol. 14, no. 7, pp. 353–356, 1993. View at Google Scholar · View at Scopus
  15. G. S. Vince, P. M. Starkey, R. Austgulen, D. Kwiatkowski, and C. W. G. Redman, “Interleukin-6, tumour necrosis factor and soluble tumour necrosis factor receptors in women with pre-eclampsia,” British Journal of Obstetrics and Gynaecology, vol. 102, no. 1, pp. 20–25, 1995. View at Google Scholar · View at Scopus
  16. M. J. Mulla, J. J. Brosens, L. W. Chamley et al., “Antiphospholipid antibodies induce a pro-inflammatory response in first trimester trophoblast via the TLR4/MyD88 pathway,” American Journal of Reproductive Immunology, vol. 62, no. 2, pp. 96–111, 2009. View at Publisher · View at Google Scholar · View at Scopus
  17. V. M. Abrahams, I. Visintin, P. B. Aldo, S. Guller, R. Romero, and G. Mor, “A role for TLRs in the regulation of immune cell migration by first trimester trophoblast cells,” Journal of Immunology, vol. 175, no. 12, pp. 8096–8104, 2005. View at Google Scholar · View at Scopus
  18. C. J. Lockwood, C. F. Yen, M. Basar et al., “Preeclampsia-related inflammatory cytokines regulate interleukin-6 expression in human decidual cells,” American Journal of Pathology, vol. 172, no. 6, pp. 1571–1579, 2008. View at Publisher · View at Google Scholar · View at Scopus
  19. K. N. Evans, L. Nguyen, J. Chan et al., “Effects of 25-hydroxyvitamin D3 and 1,25-dihydroxyvitamin D 3 on cytokine production by human decidual cells,” Biology of Reproduction, vol. 75, no. 6, pp. 816–822, 2006. View at Publisher · View at Google Scholar · View at Scopus
  20. R. E. Gandley, J. Rohland, Y. Zhou et al., “Increased myeloperoxidase in the placenta and circulation of women with preeclampsia,” Hypertension, vol. 52, no. 2, pp. 387–393, 2008. View at Publisher · View at Google Scholar · View at Scopus
  21. B. Borekci, H. Aksoy, R. A. Al, B. Demircan, and S. Kadanali, “Maternal serum interleukin-10, interleukin-2 and interleukin-6 in pre-eclampsia and eclampsia,” American Journal of Reproductive Immunology, vol. 58, no. 1, pp. 56–64, 2007. View at Publisher · View at Google Scholar · View at Scopus
  22. D. F. Benyo, A. Smarason, C. W. G. Redman, C. Sims, and K. P. Conrad, “Expression of inflammatory cytokines in placentas from women with preeclampsia,” Journal of Clinical Endocrinology and Metabolism, vol. 86, no. 6, pp. 2505–2512, 2001. View at Publisher · View at Google Scholar · View at Scopus
  23. S. Gupta, N. Aziz, L. Sekhon et al., “Lipid peroxidation and antioxidant status in preeclampsia: a systematic review,” Obstetrical and Gynecological Survey, vol. 64, no. 11, pp. 750–759, 2009. View at Publisher · View at Google Scholar · View at Scopus
  24. M. T. M. Raijmakers, R. Dechend, and L. Poston, “Oxidative stress and preeclampsia: rationale for antioxidant clinical trials,” Hypertension, vol. 44, no. 4, pp. 374–380, 2004. View at Publisher · View at Google Scholar · View at Scopus
  25. R. Aliyazicioglu, S. Guven, A. Mentese et al., “Serum anti-carbonic anhydrase II antibodies and oxidant-antioxidant balance in pre-eclampsia,” American Journal of Reproductive Immunology, vol. 66, no. 4, pp. 297–303, 2011. View at Publisher · View at Google Scholar · View at Scopus
  26. J. L. Van Der Merwe, D. R. Hall, C. Wright, P. Schubert, and D. Grové, “Are early and late preeclampsia distinct subclasses of the diseasewhat does the placenta reveal,” Hypertension in Pregnancy, vol. 29, no. 4, pp. 457–467, 2010. View at Publisher · View at Google Scholar · View at Scopus
  27. ACOG Committee on Practice Bulletins, Obstetrics, “ACOG practice bulletin. Diagnosis and management of preeclampsia and eclampsia,” Obstetrics & Gynecology, vol. 99, no. 1, pp. 159–167, 2002. View at Google Scholar
  28. H. H. Draper and M. Hadley, “Malondialdehyde determination as index of lipid peroxidation,” Methods in Enzymology, vol. 186, pp. 421–431, 1990. View at Publisher · View at Google Scholar · View at Scopus
  29. R. L. Levine, J. A. Williams, E. R. Stadtman, and E. Shacter, “Carbonyl assays for determination of oxidatively modified proteins,” Methods in Enzymology, vol. 233, pp. 346–357, 1994. View at Publisher · View at Google Scholar · View at Scopus
  30. L. Liaudet, J. G. Mabley, F. G. Soriano et al., “Inosine reduces systemic inflammation and improves survival in septic shock induced by cecal ligation and puncture,” American Journal of Respiratory and Critical Care Medicine, vol. 164, no. 7, pp. 1213–1220, 2001. View at Google Scholar · View at Scopus
  31. C. T. De Souza, A. L. Gasparetti, M. Pereira-da-Silva et al., “Peroxisome proliferator-activated receptor γ coactivator-1-dependent uncoupling protein-2 expression in pancreatic islets of rats: a novel pathway for neural control of insulin secretion,” Diabetologia, vol. 46, no. 11, pp. 1522–1531, 2003. View at Publisher · View at Google Scholar · View at Scopus