Schizandrin, an Antioxidant Lignan from Schisandra chinensis, Ameliorates Aβ_1–42-Induced Memory Impairment in Mice

Figure 3

Effects of SCH against Aβ _1–42-induced memory impairment on average escape latency time of the water maze test. Sham-operated and control groups: mice were given distilled water orally (20 mL/kg). Positive control: mice were given DPZ 0.65 mg/kg, i.g. SCH-4, SCH-12, and SCH-36: mice were given 4, 12, and 36 mg/kg of SCH, i.g., respectively. Values indicated mean ± S.E.M. and were analyzed by a two-way analysis of variance (ANOVA) followed by the Bonferroni post hoc test (𝑛=8-10). ^#𝑃<0.05 compared with the sham-operated group; ^∗𝑃<0.05, ^∗∗𝑃<0.01 compared with the control group.