Blockade of TGF-𝜷 1 Signalling Inhibits Cardiac NADPH Oxidase Overactivity in Hypertensive Rats

Figure 6

Cardiac mRNA levels of genes assessing collagen metabolism. Cardiac mRNA expression of TGF-β 1, connective tissue growth factor (CTGF), fibronectin, biglycan, and lysyl oxidase (LOX) as a ratio of gene to 18S values. Histogram represents mean ± SEM (𝑛=10). V-WKY means vehicle-treated normotensive rat; P144-WKY, P144-treated WKY rat; V-SHR, vehicle-treated spontaneously hypertensive rat; P144-SHR, P144-treated SHR. *𝑃<0.05 and **𝑃<0.01  versus V-WKY; ^†𝑃<0.05 and ^††𝑃<0.01 versus V-SHR.