The Critical Role of Redox Homeostasis in Shikonin-Induced HL-60 Cell Differentiation via Unique Modulation of the Nrf2/ARE Pathway
Figure 3
The role of intercellular redox homeostasis in Shikonin-induced HL-60 cell differentiation. The effects of the GSH modulators on intracellular ROS (a) and GSH (b) levels in HL-60 cells after 4 h of Shikonin treatment. The effects of the GSH modulators SOD, Tiron, BSO, NAC, CAT, and GSH-EE on NBT-reducing activity (c) and the mRNA expression levels of CD11b and CD14 (d) in HL-60 cells after 72 h of Shikonin treatment. SK mean Shikonin treatment. #, ## compared to the Shikonin-treated (100 ng/mL) group.
