Simvastatin Attenuates Contrast-Induced Nephropathy through Modulation of Oxidative Stress, Proinflammatory Myeloperoxidase, and Nitric Oxide

Table 2

Effect of simvastatin on tubular injury scores in a rat model of CM nephropathy.

Groups	Tubular dilatation	Tubular vacuolation	Tubular necrosis	Kidney wt/Body wt ratio (%)
Control	0	0	0	0.33 ± 0.01
Glycerol	2.7±0.28 ***	0.6 ± 0.20*	0.70 ± 0.18**	0.58 ± 0.04***
CM + glycerol	3.4 ± 0.32***	2.9 ± 0.29***	3.0 ± 0.26***	0.61 ± 0.04***
CM + glycerol + SSTN 15	2.3 ± 0.28^#	1.0 ± 0.01^###	0.40 ± 0.20^##	0.50 ± 0.03^#
CM + glycerol + SSTN 30	1.9 ± 0.22^###	0.9 ± 0.01^###	0 ± 0^###	0.48 ± 0.03^#
CM + glycerol + SSTN 60	1.2 ± 0.2^###	0.4 ± 0.24^###	0	0.47 ± 0.03^##
SSTN 60	0	0	0	0.31 ± 0.00

Values are mean ± SEM. *𝑃<0.05, **𝑃<0.01, and ***𝑃<0.001 versus control group; ^#𝑃<0.05, ^##𝑃<0.01, and ^###𝑃<0.001 versus glycerol + CM group using Tukey’s test.
High scores indicate severe injury.