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Oxidative Medicine and Cellular Longevity
Volume 2012, Article ID 854065, 6 pages
http://dx.doi.org/10.1155/2012/854065
Research Article

Thymoquinone, the Nigella sativa Bioactive Compound, Prevents Circulatory Oxidative Stress Caused by 1,2-Dimethylhydrazine in Erythrocyte during Colon Postinitiation Carcinogenesis

1Research Unit of Cancer Biology and Genetics, Hematologic, and Autoimmune Diseases, Faculty of Pharmacy of Monastir, University of Monastir, 5000 Monastir, Tunisia
2Research Unit of Human Nutrition & Metabolic Disorder, USCR Mass Spectrometry, Faculty of Medicine of Monastir, University of Monastir, 5000 Monastir, Tunisia

Received 1 December 2011; Revised 7 January 2012; Accepted 30 January 2012

Academic Editor: Ersin Fadillioglu

Copyright © 2012 Hanene Jrah Harzallah et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

We have performed this study to investigate the modulatory effect of thymoquinone (TQ), the Nigella sativa active compound, on erythrocyte lipid peroxidation and antioxidant status during 1,2-dimethylhydrazine- (DMH-) induced colon carcinogenesis after initiation in male Wistar rats. Rats exposed to DMH showed an increase of malondialdehyde and conjugated diene levels, and an augmentation of enzyme activities like catalase, glutathione peroxidase, and superoxide dismutase activities was also noted. The TQ pretreatment restored the parameters cited above to near-normal values. However, the posttreatment shows an activity similar as that presented by DMH. Therefore, our investigation revealed that TQ was a useful compound preventing DMH-induced erythrocyte damages.