Thymoquinone, the <i>Nigella sativa</i> Bioactive Compound, Prevents Circulatory Oxidative Stress Caused by 1,2-Dimethylhydrazine in Erythrocyte during Colon Postinitiation Carcinogenesis

<table>Erythrocyte CAT activity in adult rats of controls or treated with DMH, TQ, and different (TQ + DMH) treatments. Values are means ± SE for five rats in each group. DMH, TQ, and different (TQ + DMH) groups versus control group: <svg height="17.825001" id="M4" style="vertical-align:-3.276pt" version="1.1" viewbox="0 0 69.150002 17.825001" width="69.150002" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
<g transform="matrix(.012,-0,0,-.012,2.9,5.525)"><use xlink:href="#x2217"></use></g>
<g transform="matrix(.017,-0,0,-.017,10.5,14.875)"><use xlink:href="#x1D443"></use></g><g transform="matrix(.017,-0,0,-.017,26.037,13.688)"><use xlink:href="#x3C"></use></g><g transform="matrix(.017,-0,0,-.017,40.724,13.688)"><use xlink:href="#x30"></use></g><g transform="matrix(.017,-0,0,-.017,48.884,13.688)"><use xlink:href="#x2E"></use></g><g transform="matrix(.017,-0,0,-.017,52.76,13.688)"><use xlink:href="#x30"></use></g><g transform="matrix(.017,-0,0,-.017,60.919,13.688)"><use xlink:href="#x35"></use></g>
</svg>; <svg height="17.825001" id="M5" style="vertical-align:-3.276pt" version="1.1" viewbox="0 0 76.137497 17.825001" width="76.137497" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
<g transform="matrix(.012,-0,0,-.012,2.9,5.525)"><use xlink:href="#x2217"></use></g><g transform="matrix(.012,-0,0,-.012,9.885,5.525)"><use xlink:href="#x2217"></use></g>
<g transform="matrix(.017,-0,0,-.017,17.488,14.875)"><use xlink:href="#x1D443"></use></g><g transform="matrix(.017,-0,0,-.017,33.025,13.688)"><use xlink:href="#x3C"></use></g><g transform="matrix(.017,-0,0,-.017,47.712,13.688)"><use xlink:href="#x30"></use></g><g transform="matrix(.017,-0,0,-.017,55.871,13.688)"><use xlink:href="#x2E"></use></g><g transform="matrix(.017,-0,0,-.017,59.747,13.688)"><use xlink:href="#x30"></use></g><g transform="matrix(.017,-0,0,-.017,67.906,13.688)"><use xlink:href="#x31"></use></g>
</svg>; <svg height="17.825001" id="M6" style="vertical-align:-3.276pt" version="1.1" viewbox="0 0 91.275002 17.825001" width="91.275002" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
<g transform="matrix(.012,-0,0,-.012,2.9,5.525)"><use xlink:href="#x2217"></use></g><g transform="matrix(.012,-0,0,-.012,9.885,5.525)"><use xlink:href="#x2217"></use></g><g transform="matrix(.012,-0,0,-.012,16.869,5.525)"><use xlink:href="#x2217"></use></g>
<g transform="matrix(.017,-0,0,-.017,24.475,14.875)"><use xlink:href="#x1D443"></use></g><g transform="matrix(.017,-0,0,-.017,40,13.688)"><use xlink:href="#x3C"></use></g><g transform="matrix(.017,-0,0,-.017,54.704,13.688)"><use xlink:href="#x30"></use></g><g transform="matrix(.017,-0,0,-.017,62.863,13.688)"><use xlink:href="#x2E"></use></g><g transform="matrix(.017,-0,0,-.017,66.739,13.688)"><use xlink:href="#x30"></use></g><g transform="matrix(.017,-0,0,-.017,74.898,13.688)"><use xlink:href="#x30"></use></g><g transform="matrix(.017,-0,0,-.017,83.058,13.688)"><use xlink:href="#x31"></use></g>
</svg>, (TQ + DMH) groups versus DMH: <svg height="18.200001" id="M7" style="vertical-align:-3.276pt" version="1.1" viewbox="0 0 69.150002 18.200001" width="69.150002" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
<g transform="matrix(.012,-0,0,-.012,2.9,5.887)"><use xlink:href="#x2B"></use></g>
<g transform="matrix(.017,-0,0,-.017,10.5,15.237)"><use xlink:href="#x1D443"></use></g><g transform="matrix(.017,-0,0,-.017,26.037,14.05)"><use xlink:href="#x3C"></use></g><g transform="matrix(.017,-0,0,-.017,40.724,14.05)"><use xlink:href="#x30"></use></g><g transform="matrix(.017,-0,0,-.017,48.884,14.05)"><use xlink:href="#x2E"></use></g><g transform="matrix(.017,-0,0,-.017,52.76,14.05)"><use xlink:href="#x30"></use></g><g transform="matrix(.017,-0,0,-.017,60.919,14.05)"><use xlink:href="#x35"></use></g>
</svg>; <svg height="18.200001" id="M8" style="vertical-align:-3.276pt" version="1.1" viewbox="0 0 76.137497 18.200001" width="76.137497" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
<g transform="matrix(.012,-0,0,-.012,2.9,5.887)"><use xlink:href="#x2B"></use></g><g transform="matrix(.012,-0,0,-.012,9.885,5.887)"><use xlink:href="#x2B"></use></g>
<g transform="matrix(.017,-0,0,-.017,17.488,15.237)"><use xlink:href="#x1D443"></use></g><g transform="matrix(.017,-0,0,-.017,33.025,14.05)"><use xlink:href="#x3C"></use></g><g transform="matrix(.017,-0,0,-.017,47.712,14.05)"><use xlink:href="#x30"></use></g><g transform="matrix(.017,-0,0,-.017,55.871,14.05)"><use xlink:href="#x2E"></use></g><g transform="matrix(.017,-0,0,-.017,59.747,14.05)"><use xlink:href="#x30"></use></g><g transform="matrix(.017,-0,0,-.017,67.906,14.05)"><use xlink:href="#x31"></use></g>
</svg>; <svg height="18.200001" id="M9" style="vertical-align:-3.276pt" version="1.1" viewbox="0 0 91.275002 18.200001" width="91.275002" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
<g transform="matrix(.012,-0,0,-.012,2.9,5.887)"><use xlink:href="#x2B"></use></g><g transform="matrix(.012,-0,0,-.012,9.885,5.887)"><use xlink:href="#x2B"></use></g><g transform="matrix(.012,-0,0,-.012,16.869,5.887)"><use xlink:href="#x2B"></use></g>
<g transform="matrix(.017,-0,0,-.017,24.475,15.237)"><use xlink:href="#x1D443"></use></g><g transform="matrix(.017,-0,0,-.017,40,14.05)"><use xlink:href="#x3C"></use></g><g transform="matrix(.017,-0,0,-.017,54.704,14.05)"><use xlink:href="#x30"></use></g><g transform="matrix(.017,-0,0,-.017,62.863,14.05)"><use xlink:href="#x2E"></use></g><g transform="matrix(.017,-0,0,-.017,66.739,14.05)"><use xlink:href="#x30"></use></g><g transform="matrix(.017,-0,0,-.017,74.898,14.05)"><use xlink:href="#x30"></use></g><g transform="matrix(.017,-0,0,-.017,83.058,14.05)"><use xlink:href="#x31"></use></g>
</svg>. U: <i>μ</i>mol of <svg height="15.5125" id="M10" style="vertical-align:-3.276pt" version="1.1" viewbox="0 0 38.512501 15.5125" width="38.512501" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
<g transform="matrix(.017,-0,0,-.017,.062,11.363)"><path d="M729 650v-28q-62 -5 -76 -19.5t-14 -75.5v-404q0 -62 13.5 -76t75.5 -19v-28h-268v28q65 5 79.5 19t14.5 76v199h-341v-199q0 -62 14 -76t76 -19v-28h-263v28q61 5 74.5 19t13.5 76v404q0 62 -14 76t-76 19v28h259v-28q-58 -5 -71 -19t-13 -76v-162h341v162
q0 61 -13.5 75.5t-72.5 19.5v28h261z" id="x48"></path></g>
<g transform="matrix(.012,-0,0,-.012,13.087,15.45)"><path d="M412 140l28 -9q0 -2 -35 -131h-373v23q112 112 161 170q59 70 92 127t33 115q0 63 -31 98t-86 35q-75 0 -137 -93l-22 20l57 81q55 59 135 59q69 0 118.5 -46.5t49.5 -122.5q0 -62 -29.5 -114t-102.5 -130l-141 -149h186q42 0 58.5 10.5t38.5 56.5z" id="x32"></path></g>
<g transform="matrix(.017,-0,0,-.017,19.412,11.363)"><path d="M381 665q131 0 226.5 -93t95.5 -239q0 -158 -96 -253t-238 -95q-137 0 -231 95t-94 238q0 142 92.5 244.5t244.5 102.5zM359 629q-89 0 -151 -74.5t-62 -208.5q0 -141 69 -233t175 -92q90 0 150.5 74t60.5 211q0 152 -69 237.5t-173 85.5z" id="x4F"></path></g>
<g transform="matrix(.012,-0,0,-.012,32.112,15.45)"><use xlink:href="#x32"></use></g>
</svg>/min.</table>

Oxidative Medicine and Cellular Longevity

fig1

Figure 1

Figure 1: Thymoquinone, the <i>Nigella sativa</i> Bioactive Compound, Prevents Circulatory Oxidative Stress Caused by 1,2-Dimethylhydrazine in Erythrocyte during Colon Postinitiation Carcinogenesis 

Figure 1 | Thymoquinone, the Nigella sativa Bioactive Compound, Prevents Circulatory Oxidative Stress Caused by 1,2-Dimethylhydrazine in Erythrocyte during Colon Postinitiation Carcinogenesis 