Thymoquinone, the Nigella sativa Bioactive Compound, Prevents Circulatory Oxidative Stress Caused by 1,2-Dimethylhydrazine in Erythrocyte during Colon Postinitiation Carcinogenesis

Table 1

Hematologic parameters: red blood cell (RBC), hemoglobin (HGB), hematocrit (HCT), mean corpuscular volume (MCV), mean corpuscular hemoglobin concentration (MCHC), mean corpuscular hemoglobin (MCH), platelet (PLT), and white blood cell (WBC) of controls or treated rats with DMH, TQ, and different (TQ + DMH) treatments.

	Control	TQ	DMH	Pretreatment	Posttreatment
RBC (10^6mm^−3)	6.52 ± 0.46	5.934 ± 0.94	6.346 ± 1.1	6.73 ± 0.39	5.01±0.78^∗
HGB (g/dL)	11.48 ± 0.65	11.18 ± 1.5	10.74 ± 1.65	11.66 ± 0.40	10.88 ± 1.48
HCT (%)	32.58 ± 1.63	27.74 ± 4.36	30.4 ± 5.62	27.94 ± 1.38	34.16 ± 2.86
MCV (μm^−3)	47.78 ± 1.88	47.48 ± 0.64	47.38 ± 0.68	47.48 ± 0.63	52.62±2.133^∗∗∗+++
MCHC (g/dL)	35.40 ± 0.21	38.1 ± 1.73	36.4 ± 0.92	34.48 ± 1.16	34.08 ± 1.5
MCH (pg)	16.88 ± 0.60	17.98 ± 0.88	17.16 ± 0.36	18.24 ± 1.36	17.9 ± 0.78
PLT (10^3 mm^−3)	58.8 ± 10.96	134 ± 17.32	371.8±61.88^∗∗∗	126.8±13.68^+++	291±77.81^∗∗∗
WBC (10^3 mm^−3)	2.47 ± 0.35	3.9 ± 0.86	5.88±0.82^∗∗∗	5.3±0.63^∗∗	7.22±0.98^∗∗∗

Values are means ± SE for five rats in each group.
DMH, TQ, and different (TQ + DMH) groups versus control group: ^∗𝑃<0.05, ^∗∗𝑃<0.01, and ^∗∗∗𝑃<0.001, TQ + DMH groups versus DMH: ⁺𝑃<0.05,⁺⁺𝑃<0.01, and ⁺⁺⁺𝑃<0.001.