Combination Therapy with Losartan and Pioglitazone Additively Reduces Renal Oxidative and Nitrative Stress Induced by Chronic High Fat, Sucrose, and Sodium Intake

Figure 5

Effects of losartan (L), pioglitazone (P), and their combination (L + P) on immunohistochemical staining of nitrotyrosine in renal cortex. Representative micrographs of renal cortex from the control (a), model (b), L-treated (c), P-treated (d), and L + P-treated (e) rats. Histogram represents quantitative analysis (mean optical density) of nitrotyrosine expression (f) in each experimental group. Values are expressed as mean ± SD, 𝑛=6-7 per group. *𝑃<0.05 versus model group. ^†𝑃<0.05 versus control group. ^#𝑃<0.05 versus L + P group.

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